Single‐cell transcriptome analysis of male chicken germ cells reveals changes in signaling pathway‐related gene expression profiles during mitotic arrest
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13600
Abstract: Mitotic arrest is necessary for the embryonic development of germ cells, and thus, it is important to understand the signaling pathways that regulate mitotic arrest. Here, we investigated the signaling pathway dynamics of male embryonic… read more here.
Keywords: cell; arrest; mitotic arrest; germ cells ... See more keywords
PMN inhibits colorectal cancer cells through inducing mitotic arrest and p53-dependent apoptosis via the inhibition of tubulin polymerization.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.021
Abstract: Colorectal cancer (CRC) is the third most prevalent malignancy worldwide. New understandings about this disease are urgently required to guide clinical therapies. In this study, we focused on the effects of the small molecule PMN… read more here.
Keywords: apoptosis; colorectal cancer; crc; mitotic arrest ... See more keywords
ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest.
Sign Up to like & getrecommendations! Published in 2019 at "Cell systems"
DOI: 10.1016/j.cels.2019.01.005
Abstract: Although elevated levels of reactive oxygen species (ROS) have been observed in cancer cells and cancer cells aberrantly proliferate, it is not known whether the level of reactive oxygen species and the accumulation of oxidative… read more here.
Keywords: reactive oxygen; mitotic arrest; cell; cell cycle ... See more keywords
[P287] Investigation of radiation induced mitotic arrest in irradiated cells
Sign Up to like & getrecommendations! Published in 2018 at "Physica Medica"
DOI: 10.1016/j.ejmp.2018.06.562
Abstract: Purpose Investigation of mitotic arrest in cells irradiated to radiotherapeutic doses. Methods Chinese hamster ovary (CHO) cell line was used as an irradiation object. CHO cells were irradiated to the doses from the range (0–10 Gy)… read more here.
Keywords: radiation induced; mitotic arrest; cell; irradiated cells ... See more keywords
Identification and Preliminary Characterization of a Novel Tasquinimod Analog that Unexpectedly Induces Mitotic Arrest by Alteration of Microtubule Dynamics.
Sign Up to like & getrecommendations! Published in 2025 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.5c00521
Abstract: While investigating the SAR associated with tasquinimod, whose anticancer activity is primarily derived from inhibition of S100A9 and HDAC4, we designed and prepared several analogues. We identified a potent hit (FB2) that showed cytotoxicity against… read more here.
Keywords: microtubule dynamics; fb2; mitotic arrest; tasquinimod ... See more keywords
A CPC-shelterin-BTR axis regulates mitotic telomere deprotection
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-57456-8
Abstract: Telomeres prevent ATM activation by sequestering chromosome termini within telomere loops (t-loops). Mitotic arrest promotes telomere linearity and a localized ATM-dependent telomere DNA damage response (DDR) through an unknown mechanism. Using unbiased interactomics, biochemical screening,… read more here.
Keywords: deprotection; cpc shelterin; telomere deprotection; mitotic arrest ... See more keywords
Universal response in the RKO colon cancer cell line to distinct antimitotic therapies
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27267-7
Abstract: Both classic and newer antimitotics commonly induce a prolonged mitotic arrest in cell culture. During arrest, cells predominantly undergo one of two fates: cell death by apoptosis, or mitotic slippage and survival. To refine this… read more here.
Keywords: response; universal response; mitotic arrest; cell ... See more keywords
Analysis of the role of GSK3 in the mitotic checkpoint
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32435-w
Abstract: The mitotic checkpoint ensures proper chromosome segregation; defects in this checkpoint can lead to aneuploidy, a hallmark of cancer. The mitotic checkpoint blocks progression through mitosis as long as chromosomes remain unattached to spindle microtubules.… read more here.
Keywords: analysis role; checkpoint; mitotic checkpoint; mitotic arrest ... See more keywords
Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C Inhibitors.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer research"
DOI: 10.1158/0008-5472.can-25-0450
Abstract: The onset of acquired resistance limits the efficacy of KRASG12C inhibitors in lung cancer patients. Experiments in preclinical model systems and retrospective analyses of patients treated with these inhibitors have both suggested that the activation… read more here.
Keywords: resistance; cdk12; mitotic arrest; resistance krasg12c ... See more keywords
Abstract A32: Selective inhibition of AuroraA by LY3295668 erbumine in neuroblastoma models induces apoptosis through a combination of S-phase DNA damage and mitotic arrest
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.pedca19-a32
Abstract: Aurora kinase A (AuroraA) is a serine/threonine protein kinase critical for centrosome maturation, mitotic spindle formation, and spindle checkpoint activation. Aberrant expression of AuroraA promotes tumor initiation and disease progression, making it a promising therapeutic… read more here.
Keywords: dna damage; phase; inhibition; auroraa ... See more keywords
Abstract A001: KIF18A inhibition, via ATX020, leads to mitotic arrest and robust anti-tumor activity through a synthetic lethal interaction with chromosome instability
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1538-8514.synthleth24-a001
Abstract: This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR001) of the Conference Program/Proceedings. Citation Format: Maureen S. Lynes, Laura Ghisolfi,… read more here.
Keywords: atx020 leads; kif18a inhibition; leads mitotic; inhibition via ... See more keywords