Single‐cell transcriptome analysis of male chicken germ cells reveals changes in signaling pathway‐related gene expression profiles during mitotic arrest
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13600
Abstract: Mitotic arrest is necessary for the embryonic development of germ cells, and thus, it is important to understand the signaling pathways that regulate mitotic arrest. Here, we investigated the signaling pathway dynamics of male embryonic… read more here.
Keywords: cell; arrest; mitotic arrest; germ cells ... See more keywords
PMN inhibits colorectal cancer cells through inducing mitotic arrest and p53-dependent apoptosis via the inhibition of tubulin polymerization.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.021
Abstract: Colorectal cancer (CRC) is the third most prevalent malignancy worldwide. New understandings about this disease are urgently required to guide clinical therapies. In this study, we focused on the effects of the small molecule PMN… read more here.
Keywords: apoptosis; colorectal cancer; crc; mitotic arrest ... See more keywords
ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest.
Sign Up to like & getrecommendations! Published in 2019 at "Cell systems"
DOI: 10.1016/j.cels.2019.01.005
Abstract: Although elevated levels of reactive oxygen species (ROS) have been observed in cancer cells and cancer cells aberrantly proliferate, it is not known whether the level of reactive oxygen species and the accumulation of oxidative… read more here.
Keywords: reactive oxygen; mitotic arrest; cell; cell cycle ... See more keywords
[P287] Investigation of radiation induced mitotic arrest in irradiated cells
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DOI: 10.1016/j.ejmp.2018.06.562
Abstract: Purpose Investigation of mitotic arrest in cells irradiated to radiotherapeutic doses. Methods Chinese hamster ovary (CHO) cell line was used as an irradiation object. CHO cells were irradiated to the doses from the range (0–10 Gy)… read more here.
Keywords: radiation induced; mitotic arrest; cell; irradiated cells ... See more keywords
Universal response in the RKO colon cancer cell line to distinct antimitotic therapies
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DOI: 10.1038/s41598-018-27267-7
Abstract: Both classic and newer antimitotics commonly induce a prolonged mitotic arrest in cell culture. During arrest, cells predominantly undergo one of two fates: cell death by apoptosis, or mitotic slippage and survival. To refine this… read more here.
Keywords: response; universal response; mitotic arrest; cell ... See more keywords
Analysis of the role of GSK3 in the mitotic checkpoint
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DOI: 10.1038/s41598-018-32435-w
Abstract: The mitotic checkpoint ensures proper chromosome segregation; defects in this checkpoint can lead to aneuploidy, a hallmark of cancer. The mitotic checkpoint blocks progression through mitosis as long as chromosomes remain unattached to spindle microtubules.… read more here.
Keywords: analysis role; checkpoint; mitotic checkpoint; mitotic arrest ... See more keywords
Abstract A32: Selective inhibition of AuroraA by LY3295668 erbumine in neuroblastoma models induces apoptosis through a combination of S-phase DNA damage and mitotic arrest
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.pedca19-a32
Abstract: Aurora kinase A (AuroraA) is a serine/threonine protein kinase critical for centrosome maturation, mitotic spindle formation, and spindle checkpoint activation. Aberrant expression of AuroraA promotes tumor initiation and disease progression, making it a promising therapeutic… read more here.
Keywords: dna damage; phase; inhibition; auroraa ... See more keywords
Novel therapeutic strategy to inhibit growth of pancreatic cancer organoids using a rational combination of drugs to induce mitotic arrest and apoptosis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.322
Abstract: 322Background: The ability of cancer cells to suppress apoptosis is critical for carcinogenesis. The Bcl-2-family of regulator proteins, including the anti-apoptotic members Bcl-2, Bcl-xL and Mcl-1, contributes to a complex network in control of apoptosis.… read more here.
Keywords: combination; apoptosis; pancreatic cancer; cancer organoids ... See more keywords
RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4123438
Abstract: We synthesized a new inhibitor of tubulin polymerization, the pyrrole (1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-1H-pyrrol-3-yl)(3,4,5-trimethoxy-phenyl)methanone 6 (RS6077). Compound 6 inhibited the growth of multiple cancer cell lines, with IC50 values in the nM range, without affecting the growth… read more here.
Keywords: cell lines; cell; cell death; mitotic arrest ... See more keywords
Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling
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DOI: 10.3389/fonc.2020.01274
Abstract: Combination therapies that display cancer-killing activities through either coexistent targeting of several cellular factors or more efficient suppression of a specific pathway are generally used in cancer treatment. Sildenafil, a specific phosphodiesterase type 5 (PDE5)… read more here.
Keywords: vincristine; vincristine induced; sildenafil; cancer ... See more keywords
Bcl-xL activity influences outcome of the mitotic arrest
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.933112
Abstract: Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic agents against different tumors for more than 30 years because of their ability to block mitotic progression by disrupting the mitotic spindle and… read more here.
Keywords: mitotic slippage; arrest; mitotic arrest; mitotic inhibitors ... See more keywords