Purging human ovarian cortex of contaminating leukaemic cells by targeting the mitotic catastrophe signalling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-021-02081-9
Abstract: Is it possible to eliminate metastasised chronic myeloid leukaemia (CML) and acute myeloid leukaemia (AML) cells from ovarian cortex fragments by inhibition of Aurora B/C kinases (AURKB/C) without compromising ovarian tissue or follicles? Human ovarian… read more here.
Keywords: ovarian cortex; cortex; treatment; tissue ... See more keywords
Escape from mitotic catastrophe by actin-dependent nuclear displacement in fission yeast
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DOI: 10.1016/j.isci.2020.102031
Abstract: Summary Eukaryotic cells position the nucleus within the proper intracellular space, thereby safeguarding a variety of cellular processes. In fission yeast, the interphase nucleus is placed in the cell middle in a microtubule-dependent manner. By… read more here.
Keywords: fission; mitotic catastrophe; actin dependent; fission yeast ... See more keywords
Strategic inhibition of CEP55 in aggressive breast cancer leads to mitotic catastrophe
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz238.001
Abstract: Abstract Background Triple negative breast cancers (TNBCs), with negligible ER, PR expression and HER2 amplification are the most aggressive form of breast cancer (BC). Due to the high level of genomic instability, treatment of TNBC… read more here.
Keywords: breast; cep55; inhibition; breast cancer ... See more keywords
Publisher's Note: Chromosomal breaks during mitotic catastrophe trigger γH2AX–ATM–p53-mediated apoptosis. J. Cell Sci. doi: 10.1242/jcs.081612
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.210682
Abstract: This Publisher's Note updates and replaces the Expression of Concern ([doi: 10.1242/jcs.205559][1]) relating to the article ‘Chromosomal breaks during mitotic catastrophe trigger γH2AX–ATM–p53-mediated apoptosis’ by Gabriela Imreh, Helin Vakifahmetoglu Norberg, Stefan Imreh and Boris read more here.
Keywords: chromosomal breaks; breaks mitotic; publisher note; mitotic catastrophe ... See more keywords
Mitotic catastrophe and cell cycle arrest are alternative cell death pathways executed by bortezomib in rituximab resistant B-cell lymphoma cells
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DOI: 10.18632/oncotarget.14405
Abstract: The ubiqutin-proteasome system (UPS) plays a role in rituximab-chemotherapy resistance and bortezomib (BTZ) possesses caspase-dependent (i.e. Bak stabilization) and a less characterized caspase–independent mechanism-of-action(s). Here, we define BTZ-induced caspase-independent cell death pathways. A panel of… read more here.
Keywords: btz; mitotic catastrophe; cell; cell cycle ... See more keywords
Induction of Mitotic Catastrophe in Human Cervical Cancer Cells After Administration of Aloe-emodin.
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DOI: 10.21873/anticanres.12443
Abstract: BACKGROUND Aloe-emodin is an anthraquinone with potential pharmacological properties, including numerous antitumor properties. The purpose of the study was to determine whether aloe-emodin induces mitotic death in cervical cancer cells. MATERIALS AND METHODS Analysis of… read more here.
Keywords: aloe emodin; mitotic catastrophe; cervical cancer; cancer cells ... See more keywords
KDM5D Histone Demethylase Identifies Platinum-Tolerant Head and Neck Cancer Cells Vulnerable to Mitotic Catastrophe
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065310
Abstract: Head and neck squamous cell carcinoma (HNSCC) is a major contributor to cancer incidence globally and is currently managed by surgical resection followed by adjuvant chemoradiotherapy. However, local recurrence is the major cause of mortality,… read more here.
Keywords: demethylase; persister cells; mitotic catastrophe; persister ... See more keywords