Stabilization of P/CAF, as a ubiquitin ligase toward MDM2, suppresses mitotic cell death through p53-p21 activation in HCT116 cells with SIRT2 suppression.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.11.136
Abstract: We previously reported that the suppression of SIRT2, an NAD + -dependent protein deacetylases, induces p53 accumulation via degradation of p300 and the subsequent MDM2 degradation, eventually leading to apoptosis in HeLa cells. The present study identified… read more here.
Keywords: mitotic cell; suppression; mdm2; sirt2 suppression ... See more keywords
Efficient automated detection of mitotic cells from breast histological images using deep convolution neutral network with wavelet decomposed patches
Sign Up to like & getrecommendations! Published in 2019 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2018.11.001
Abstract: In medical practice, the mitotic cell count from histological images acts as a proliferative marker for cancer diagnosis. Therefore, an accurate method for detecting mitotic cells in histological images is essential for cancer screening. Manual… read more here.
Keywords: mitotic cell; detection; automated detection; detection mitotic ... See more keywords
Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling
Sign Up to like & getrecommendations! Published in 2018 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0247-4
Abstract: Tissue morphogenesis is driven by mechanical forces that elicit changes in cell size, shape and motion. The extent by which forces deform tissues critically depends on the rheological properties of the recipient tissue. Yet, whether… read more here.
Keywords: mitotic cell; tissue; non canonical; cell rounding ... See more keywords
Permitted and restricted steps of human kinetochore assembly in mitotic cell extracts
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e20-07-0461
Abstract: Mitotic kinetochores assemble via the hierarchical recruitment of numerous cytosolic components to the centromere region of each chromosome. However, how these orderly and localized interactions are achieved without spurious macromolecular assemblies forming from soluble kinetochore… read more here.
Keywords: mitotic cell; microtubule binding; kinetochore; cell ... See more keywords
WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death
Sign Up to like & getrecommendations! Published in 2017 at "Science Advances"
DOI: 10.1126/sciadv.1700090
Abstract: WNT antagonism displays marked synergy with taxane chemotherapy and reverses taxane-induced enrichment of cancer stem cells. The WNT pathway mediates intercellular signaling that regulates cell fate in both normal development and cancer. It is widely… read more here.
Keywords: wnt antagonists; activity taxanes; mitotic cell; wnt ... See more keywords
Rnd3 interacts with TAO kinases and contributes to mitotic cell rounding and spindle positioning
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.235895
Abstract: ABSTRACT Rnd3 is an atypical Rho family protein that is constitutively GTP bound, and acts on membranes to induce loss of actin stress fibers and cell rounding. Phosphorylation of Rnd3 promotes 14-3-3 binding and its… read more here.
Keywords: mitotic cell; rounding spindle; spindle positioning; cell rounding ... See more keywords
Amn1 governs post-mitotic cell separation in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007691
Abstract: Post-mitotic cell separation is one of the most prominent events in the life cycle of eukaryotic cells, but the molecular underpinning of this fundamental biological process is far from being concluded and fully characterized. We… read more here.
Keywords: mitotic cell; saccharomyces cerevisiae; post mitotic; cell separation ... See more keywords