Spatiotemporal regulation of the Dma1-mediated mitotic checkpoint coordinates mitosis with cytokinesis
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DOI: 10.1007/s00294-018-0921-x
Abstract: During cell division, the timing of mitosis and cytokinesis must be ordered to ensure that each daughter cell receives a complete, undamaged copy of the genome. In fission yeast, the septation initiation network (SIN) is… read more here.
Keywords: mitosis cytokinesis; dma1; cytokinesis; checkpoint ... See more keywords
Basis of catalytic assembly of the mitotic checkpoint complex
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DOI: 10.1038/nature21384
Abstract: In mitosis, for each daughter cell to inherit an accurate copy of the genome from the mother cell, sister chromatids in the mother cell must attach to microtubules emanating from opposite poles of the mitotic… read more here.
Keywords: mcc; conversion; sac; mad2 ... See more keywords
Analysis of the role of GSK3 in the mitotic checkpoint
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DOI: 10.1038/s41598-018-32435-w
Abstract: The mitotic checkpoint ensures proper chromosome segregation; defects in this checkpoint can lead to aneuploidy, a hallmark of cancer. The mitotic checkpoint blocks progression through mitosis as long as chromosomes remain unattached to spindle microtubules.… read more here.
Keywords: analysis role; checkpoint; mitotic checkpoint; mitotic arrest ... See more keywords
The mitotic checkpoint is a targetable vulnerability of carboplatin-resistant triple negative breast cancers
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DOI: 10.1038/s41598-021-82780-6
Abstract: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, lacking effective therapy. Many TNBCs show remarkable response to carboplatin-based chemotherapy, but often develop resistance over time. With increasing use of carboplatin in the… read more here.
Keywords: breast; carboplatin resistant; carboplatin; mitotic checkpoint ... See more keywords
Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121478119
Abstract: Significance The mitotic checkpoint system is essential for the prevention of mistakes in the segregation of chromosomes in mitosis. As long as chromosomes are not attached correctly to the mitotic spindle, a mitotic checkpoint complex… read more here.
Keywords: ligase ubr5; mitotic checkpoint; ligase; checkpoint ... See more keywords
BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) promotes lung adenocarcinoma by interacting with Zinc Finger Protein ZNF143 and regulating glycolysis
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DOI: 10.1080/21655979.2021.2013108
Abstract: ABSTRACT Lung adenocarcinoma (LUAD) is one of the most common causes of cancer death in men. BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B) has been reported to contribute to the initiation and development of several… read more here.
Keywords: bub1b bub1; bub1 mitotic; lung adenocarcinoma; luad ... See more keywords
PO-224 consequences of FOXP1-mediated transcriptional repression of the mitotic checkpoint gene MAD2 in breast cancer
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DOI: 10.1136/esmoopen-2018-eacr25.742
Abstract: Introduction The mitotic checkpoint, or spindle assembly checkpoint (SAC), is a safeguard mechanism that prevents chromosome missegregation during mitosis. It is well established that overexpression of the mitotic checkpoint component MAD2 leads to chromosome instability… read more here.
Keywords: cancer; expression; mitotic checkpoint; breast cancer ... See more keywords
Polymorphisms in mitotic checkpoint-related genes can influence survival outcomes of early-stage non-small cell lung cancer
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DOI: 10.1183/1393003.congress-2017.pa2040
Abstract: This study was conducted to investigate the association between single nucleotide polymorphisms (SNPs) in mitotic checkpoint-related genes and clinical outcomes of surgically resected non-small cell lung cancer (NSCLC). A total of 766 patients with NSCLC… read more here.
Keywords: survival outcomes; checkpoint related; related genes; mitotic checkpoint ... See more keywords
Implications of alternative routes to APC/C inhibition by the mitotic checkpoint complex
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DOI: 10.1371/journal.pcbi.1006449
Abstract: The mitotic checkpoint (also called spindle assembly checkpoint) is a signaling pathway that ensures faithful chromosome segregation. Mitotic checkpoint proteins inhibit the anaphase-promoting complex (APC/C) and its activator Cdc20 to prevent precocious anaphase. Checkpoint signaling… read more here.
Keywords: implications alternative; alternative routes; apc inhibition; checkpoint ... See more keywords
MAD1: Kinetochore Receptors and Catalytic Mechanisms
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DOI: 10.3389/fcell.2018.00051
Abstract: The mitotic checkpoint monitors kinetochore-microtubule attachment, delays anaphase onset and prevents aneuploidy when unattached or tensionless kinetochores are present in cells. Mitotic arrest deficiency 1 (MAD1) is one of the evolutionarily conserved core mitotic checkpoint… read more here.
Keywords: kinetochore receptors; mad1 kinetochore; receptors catalytic; catalytic mechanisms ... See more keywords