Mitotic chromosome organization: General rules meet species-specific variability
Sign Up to like & getrecommendations! Published in 2020 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2020.01.006
Abstract: Research on the formation of mitotic chromosomes from interphase chromatin domains, ongoing for several decades, made significant progress in recent years. It was stimulated by the development of advanced microscopic techniques and implementation of chromatin… read more here.
Keywords: chromosome organization; mitotic chromosomes; organization general; mitotic chromosome ... See more keywords
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-50702-2
Abstract: The human polo-like kinase PLK1 coordinates mitotic chromosome segregation by phosphorylating multiple chromatin- and kinetochore-binding proteins. How PLK1 activity is directed to specific substrates via phosphopeptide recognition by its carboxyl-terminal polo-box domain (PBD) is poorly… read more here.
Keywords: mitotic chromosome; pocket; plk1; chromosome segregation ... See more keywords
Regulation of the mitotic chromosome folding machines
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DOI: 10.1042/bcj20210140
Abstract: Over the last several years enormous progress has been made in identifying the molecular machines, including condensins and topoisomerases that fold mitotic chromosomes. The discovery that condensins generate chromatin loops through loop extrusion has revolutionized,… read more here.
Keywords: regulation mitotic; folding machines; chromosome folding; chromosome ... See more keywords
Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2210593120
Abstract: Significance During the interphase of the cell cycle, chromatin is accessible to the transcription machinery, which allows gene expression. When cells enter mitosis, chromosomes strongly condense, which facilitates their symmetrical segregation at the end of… read more here.
Keywords: condensation; chromosome condensation; gene expression; mitotic chromosome ... See more keywords