Mitotic chromosome organization: General rules meet species-specific variability
Sign Up to like & getrecommendations! Published in 2020 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2020.01.006
Abstract: Research on the formation of mitotic chromosomes from interphase chromatin domains, ongoing for several decades, made significant progress in recent years. It was stimulated by the development of advanced microscopic techniques and implementation of chromatin… read more here.
Keywords: chromosome organization; mitotic chromosomes; organization general; mitotic chromosome ... See more keywords
The mechanics of mitotic chromosomes
Sign Up to like & getrecommendations! Published in 2021 at "Quarterly Reviews of Biophysics"
DOI: 10.1017/s0033583521000081
Abstract: Abstract Condensation and faithful separation of the genome are crucial for the cellular life cycle. During chromosome segregation, mechanical forces generated by the mitotic spindle pull apart the sister chromatids. The mechanical nature of this… read more here.
Keywords: microscopy; mechanical properties; mitotic chromosomes; structure ... See more keywords
Single-Molecule Micromanipulation and Super-Resolution Imaging Resolve Nanodomains Underlying Chromatin Folding in Mitotic Chromosomes.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c01025
Abstract: The folding of interphase chromatin into highly compact mitotic chromosomes is one of the most recognizable changes during the cell cycle. However, the structural organization underlying this drastic compaction remains elusive. Here, we combine several… read more here.
Keywords: single molecule; microscopy; super resolution; mitotic chromosomes ... See more keywords
Visualization of the three-dimensional structure of the human centromere in mitotic chromosomes by super-resolution microscopy.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-08-0332
Abstract: The human centromere comprises large arrays of repetitive alpha-satellite DNA at the primary constriction of mitotic chromosomes. In addition, centromeres are epigenetically specified by the centromere-specific histone H3 variant CENP-A that supports kinetochore assembly to… read more here.
Keywords: microscopy; mitotic chromosomes; human centromere; satellite dna ... See more keywords
Heat shock transcription factors demonstrate a distinct mode of interaction with mitotic chromosomes.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad304
Abstract: A large number of transcription factors have been shown to bind and interact with mitotic chromosomes, which may promote the efficient reactivation of transcriptional programs following cell division. Although the DNA-binding domain (DBD) contributes strongly… read more here.
Keywords: transcription factors; mitotic chromosomes; heat shock;
Obtaining Polytene, Meiotic, and Mitotic Chromosomes from Mosquitoes for Cytogenetic Analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor protocols"
DOI: 10.1101/pdb.prot107872
Abstract: Chromosome visualization is a key step for developing cytogenetic maps and idiograms, analyzing inversion polymorphisms, and identifying mosquito species. Three types of chromosomes-polytene, mitotic, and meiotic-are used in cytogenetic studies of mosquitoes. Here, we describe… read more here.
Keywords: mosquitoes cytogenetic; obtaining polytene; chromosomes mosquitoes; mitotic chromosomes ... See more keywords