Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells.
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DOI: 10.1073/pnas.2103585118
Abstract: Mitotic errors can activate cyclic GMP-AMP synthase (cGAS) and induce type I interferon (IFN) signaling. Current models propose that chromosome segregation errors generate micronuclei whose rupture activates cGAS. We used a panel of antimitotic drugs… read more here.
Keywords: chromatin bridges; mitotic errors; micronuclei activate; chromatin ... See more keywords