Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02030
Abstract: Chromosomal instability (CIN) is a hallmark of cancer that results from errors in chromosome segregation during mitosis. Targeting of CIN-associated vulnerabilities is an emerging therapeutic strategy in drug development. KIF18A, a mitotic kinesin, has been… read more here.
Keywords: mitotic kinesin; kif18a; kinesin kif18a; chemical ... See more keywords
Non‐canonical functions of the mitotic kinesin Eg5
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DOI: 10.1111/1759-7714.12792
Abstract: Kinesins are widely expressed, microtubule‐dependent motors that play vital roles in microtubule‐associated cellular activities, such as cell division and intracellular transport. Eg5, also known as kinesin‐5 or kinesin spindle protein, is a member of the… read more here.
Keywords: eg5; non canonical; mitotic kinesin; kinesin ... See more keywords
Abstract 4965: Targeting the mitotic kinesin, KIF18A, in chromosomally unstable cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4965
Abstract: Background: Chromosome instability (CIN), characterized by frequent and ongoing loss or gain of chromosome number, is commonly observed in tumor cells. Although long recognized as a vulnerability of cancer cells, potential CIN-selective therapeutic targets have… read more here.
Keywords: small molecule; mitotic kinesin; kif18a; kinesin kif18a ... See more keywords
The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry
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DOI: 10.7554/elife.27793
Abstract: MKLP2, a kinesin-6, has critical roles during the metaphase-anaphase transition and cytokinesis. Its motor domain contains conserved nucleotide binding motifs, but is divergent in sequence (~35% identity) and size (~40% larger) compared to other kinesins.… read more here.
Keywords: divergent mitotic; mklp2; mitotic kinesin; motor ... See more keywords