An Aurora kinase inhibitor, AMG900, inhibits glioblastoma cell proliferation by disrupting mitotic progression
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1771
Abstract: The Aurora kinase family of serine/threonine protein kinases comprises Aurora A, B, and C and plays an important role in mitotic progression. Several inhibitors of Aurora kinase have been developed as anti‐cancer therapeutics. Here, we… read more here.
Keywords: glioblastoma; mitotic progression; aurora kinase; progression ... See more keywords
Dynamics of kinetochore structure and its regulations during mitotic progression
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03472-4
Abstract: Faithful chromosome segregation during mitosis in eukaryotes requires attachment of the kinetochore, a large protein complex assembled on the centromere of each chromosome, to the spindle microtubules. The kinetochore is a structural interface for the… read more here.
Keywords: kinetochore structure; microscopy; mitotic progression; structure regulations ... See more keywords
LY6K-AS lncRNA is a lung adenocarcinoma prognostic biomarker and regulator of mitotic progression
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DOI: 10.1038/s41388-021-01696-7
Abstract: Recent advances in genomics unraveled several actionable mutational drivers in lung cancer, leading to promising therapies such as tyrosine kinase inhibitors and immune checkpoint inhibitors. However, the tumors’ acquired resistance to the newly-developed as well… read more here.
Keywords: lung adenocarcinoma; mitotic progression; lung cancer; ly6k ... See more keywords
Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression
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DOI: 10.1158/1541-7786.mcr-17-0670
Abstract: Mitotic progression is regulated largely by reversible phosphorylation events that are mediated by mitotic kinases and phosphatases. Protein phosphatase 1 (PP1) has been shown to play a crucial role in regulation of mitotic entry, progression,… read more here.
Keywords: phosphatase nuclear; nuclear targeting; aurora kinases; mitotic progression ... See more keywords
PCTAIRE1 promotes mitotic progression and resistance against antimitotic and apoptotic signals
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DOI: 10.1242/jcs.258831
Abstract: ABSTRACT PCTAIRE1 (also known as CDK16) is a serine-threonine kinase implicated in physiological processes like neuronal development, vesicle trafficking, spermatogenesis and cell proliferation. However, its exact role in cell division remains unclear. In this study,… read more here.
Keywords: mitotic progression; resistance; pctaire1 promotes; pctaire1 ... See more keywords
Cytotoxicity of 9,10-Phenanthrenequinone Impairs Mitotic Progression and Spindle Assembly Independent of ROS Production in HeLa Cells
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DOI: 10.3390/toxics10060327
Abstract: The polycyclic aromatic hydrocarbon quinone derivative 9,10-phenanthrenequinone (9,10-PQ) is one of the most abundant and toxic components found in diesel exhaust particles (DEPs). These DEPs are created during diesel fuel combustion and are considered the… read more here.
Keywords: cytotoxicity; hela cells; mitotic progression; progression spindle ... See more keywords