G2/M arrest and mitotic slippage induced by fenbendazole in canine melanoma cells
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DOI: 10.1002/vms3.733
Abstract: Abstract Background The use of fenbendazole (FBZ) in terminal cancer patients has recently increased, as anthelminthic drugs, such as FBZ and benzimidazole, exhibit anti‐tubulin effects in tumour cells. Objectives The present study evaluated the in… read more here.
Keywords: mitotic slippage; cell; canine melanoma; melanoma ... See more keywords
Mitotic slippage and the subsequent cell fates after inhibition of Aurora B during tubulin-binding agent–induced mitotic arrest
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DOI: 10.1038/s41598-017-17002-z
Abstract: Tubulin-binding agents (TBAs) are designed to target microtubule (MT) dynamics, resulting in compromised mitotic spindles and an unsatisfied spindle assembly checkpoint. The activity of Aurora B kinase is indispensable for TBA-induced mitotic arrest, and its… read more here.
Keywords: tubulin binding; slippage; mitotic slippage; cell ... See more keywords
Bcl-xL activity influences outcome of the mitotic arrest
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.933112
Abstract: Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic agents against different tumors for more than 30 years because of their ability to block mitotic progression by disrupting the mitotic spindle and… read more here.
Keywords: mitotic slippage; arrest; mitotic arrest; mitotic inhibitors ... See more keywords