The role of TACC3 in mitotic spindle organization
Sign Up to like & getrecommendations! Published in 2017 at "Cytoskeleton"
DOI: 10.1002/cm.21388
Abstract: TACC3 regulates spindle organization during mitosis and also regulates centrosome‐mediated microtubule nucleation by affecting γ‐Tubulin ring complexes. In addition, it interacts with different proteins (such as ch‐TOG, clathrin and Aurora‐A) to function in mitotic spindle… read more here.
Keywords: spindle organization; tacc3 mitotic; tog clathrin; mitotic spindle ... See more keywords
A Cell-Based Assay for Mitotic Spindle Orientation.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7847-2_5
Abstract: The regulation of mitotic spindle orientation is essential to ensure proper cell division and development (Kiyomitsua and Cheeseman Nat Cell Biol 14:311-317, 2012). For identification of potential spindle orientation regulators, determination of the mitotic spindle… read more here.
Keywords: spindle orientation; cell based; mitotic spindle; based assay ... See more keywords
Mechanical Torque Promotes Bipolarity of the Mitotic Spindle Through Multi-centrosomal Clustering
Sign Up to like & getrecommendations! Published in 2022 at "Bulletin of Mathematical Biology"
DOI: 10.1007/s11538-021-00985-2
Abstract: Intracellular forces shape cellular organization and function. One example is the mitotic spindle, a cellular machine consisting of multiple chromosomes and centrosomes which interact via dynamic microtubule filaments and motor proteins, resulting in complicated spatially… read more here.
Keywords: mitotic spindle; bipolarity; torque promotes; mechanical torque ... See more keywords
Correlating light microscopy with serial block face scanning electron microscopy to study mitotic spindle architecture.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2018.03.010
Abstract: The mitotic spindle is a complex structure that coordinates the accurate segregation of chromosomes during cell division. To understand how the mitotic spindle operates at the molecular level, high resolution imaging is needed. Serial block… read more here.
Keywords: resolution; microscopy; sbf sem; electron microscopy ... See more keywords
TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.12.042
Abstract: The faithful inheritance of chromosomes is essential for the propagation of organisms. In eukaryotes, central to this process is the mitotic spindle. Recently, we have identified TRIM8 as a gene aberrantly expressed in gliomas whose… read more here.
Keywords: chromosomal stability; kif11 kifc1; trim8 interacts; interacts kif11 ... See more keywords
Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.09.002
Abstract: Proper organization of the mitotic spindle is key to genetic stability, but molecular components of inter-microtubule bridges that crosslink kinetochore fibers (K-fibers) are still largely unknown. Here we identify a kinase-independent function of class II… read more here.
Keywords: pi3k; breast cancer; genomic stability; stability ... See more keywords
Mechanochemical Crosstalk Produces Cell-Intrinsic Patterning of the Cortex to Orient the Mitotic Spindle
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2020.06.098
Abstract: Summary Proliferating animal cells are able to orient their mitotic spindles along their interphase cell axis, setting up the axis of cell division, despite rounding up as they enter mitosis. This has previously been attributed… read more here.
Keywords: cell axis; cell; mechanochemical crosstalk; orient mitotic ... See more keywords
Organizational Principles of the NuMA-Dynein Interaction Interface and Implications for Mitotic Spindle Functions.
Sign Up to like & getrecommendations! Published in 2020 at "Structure"
DOI: 10.1016/j.str.2020.04.017
Abstract: Mitotic progression is orchestrated by the microtubule-based motor dynein, which sustains all mitotic spindle functions. During cell division, cytoplasmic dynein acts with the high-molecular-weight complex dynactin and nuclear mitotic apparatus (NuMA) to organize and position… read more here.
Keywords: interaction interface; mitotic spindle; spindle functions; numa dynein ... See more keywords
Mitotic spindle assembly in animal cells: a fine balancing act
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/nrm.2016.162
Abstract: The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes into the two daughter cells during cell division, which is paramount for maintaining genome integrity. It is a self-organized and dynamic… read more here.
Keywords: animal cells; spindle assembly; assembly animal; cells fine ... See more keywords
Small molecule allosteric uncoupling of microtubule depolymerase activity from motility in human Kinesin-5 during mitotic spindle assembly
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-56173-9
Abstract: Human Kinesin-5 (Eg5) has a large number of known allosteric inhibitors that disrupt its mitotic function. Small-molecule inhibitors of Eg5 are candidate anti-cancer agents and important probes for understanding the cellular function. Here we show… read more here.
Keywords: microtubule; small molecule; motility; mitotic spindle ... See more keywords
Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82189-1
Abstract: Src-family tyrosine kinases (SFKs) play important roles in a number of signal transduction events during mitosis, such as spindle formation. A relationship has been reported between SFKs and the mitotic spindle; however, the underlying mechanisms… read more here.
Keywords: tyrosine phosphorylation; kinastrin; kinastrin skap; prc1 ... See more keywords