Tandem determination of mitoxantrone and ribonucleic acid using mercaptosuccinic acid-capped CdTe quantum dots
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Luminescence"
DOI: 10.1016/j.jlumin.2017.05.054
Abstract: Abstract Mercaptosuccinic acid-capped CdTe quantum dots were successfully fabricated as a simple synthesized and sensitive fluorescence sensor for tandem determination of mitoxantrone and ribonucleic acid and also monitoring their interaction. Due to the adsorption of… read more here.
Keywords: ribonucleic acid; determination; quantum dots; acid ... See more keywords
Theoretical and experimental studies on anticancer drug mitoxantrone
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.07.020
Abstract: Abstract Mitoxantrone (MX) is an important antineoplastic drug used for treatment of different types of cancer with lower side effects. The purpose of this study is to shade more light on the mechanism of interaction… read more here.
Keywords: studies anticancer; theoretical experimental; drug; experimental studies ... See more keywords
Encapsulation of Mitoxantrone within Cucurbit[8]uril Decreases Toxicity and Enhances Survival in a Mouse Model of Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.7b00090
Abstract: Mitoxantrone was efficiently encapsulated within cucurbit[8]uril in a 2:1 complex where the two mitoxantrone molecules were symmetrically located through both portals of a cucurbit[8]uril cage. The novel complex facilitates increased mitoxantrone uptake in mouse breast… read more here.
Keywords: decreases toxicity; cucurbit uril; within cucurbit; cancer ... See more keywords
Results of the randomized phase IIB ADMIRE trial of FCR with or without mitoxantrone in previously untreated CLL
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2017.65
Abstract: ADMIRE was a multicenter, randomized-controlled, open, phase IIB superiority trial in previously untreated chronic lymphocytic leukemia. Conventional front-line therapy in fit patients is fludarabine, cyclophosphamide and rituximab (FCR). Initial evidence from non-randomized phase II trials… read more here.
Keywords: trial; admire; previously untreated; randomized phase ... See more keywords
Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-10293-x
Abstract: Spike-mediated entry of SARS-CoV-2 into human airway epithelial cells is an attractive therapeutic target for COVID-19. In addition to protein receptors, the SARS-CoV-2 spike (S) protein also interacts with heparan sulfate, a negatively charged glycosaminoglycan… read more here.
Keywords: mitoxantrone; sulfate spike; heparan sulfate; sars cov ... See more keywords
A simple single jar “on–off fluorescence” designed system for the determination of mitoxantrone using an eosin Y dye in raw powder, vial, and human biofluids
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra00120a
Abstract: In this work, a direct, simple, one-pot, and green spectrofluorimetric approach was applied to measure mitoxantrone, a chemotherapeutic agent, through a green validated method. The suggested approach focused on establishing an easy association complex combining… read more here.
Keywords: system; mitoxantrone; fluorescence designed; jar fluorescence ... See more keywords
Tumor microenvironment-responsive micelles assembled from a prodrug of mitoxantrone and 1-methyl tryptophan for enhanced chemo-immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Drug Delivery"
DOI: 10.1080/10717544.2023.2182254
Abstract: Abstract Mitoxantrone (MX) can induce the immunogenic-cell death (ICD) of tumor cells and activate anti-tumor immune responses. However, it can also cause high expression of indole amine 2, 3-dioxygenase (IDO) during ICD, leading to T-cell… read more here.
Keywords: methyl tryptophan; mitoxantrone; tumor microenvironment; enhanced chemo ... See more keywords
Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in Enterococcus faecalis
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.add9280
Abstract: Among Enterococci, intrinsic and acquired resistance to antibiotics such as β-lactams and vancomycin critically limit treatment options for infection with these opportunistic pathogens. Antimicrobials that enhance the host immune response are emerging as alternative approaches,… read more here.
Keywords: vancomycin resistance; mitoxantrone; enterococcus faecalis; activity ... See more keywords
A case of mitoxantrone extravasation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/1078155219893736
Abstract: Introduction Mitoxantrone is a chemotherapeutic agent approved for various diseases. The literature has been conflicting in classifying mitoxantrone as a vesicant or irritant. Case report We report a patient who had an extravasation of mitoxantrone.… read more here.
Keywords: case mitoxantrone; extravasation; mitoxantrone extravasation; oncology ... See more keywords
Interim Analysis of a Single Arm Phase II Study of Cpi-613 in Combination with High Dose Cytarabine and Mitoxantrone for Patients with Relapsed or Refractory AML
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.2626.2626
Abstract: Background:CPI-613 is a first in class agent that inhibits pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase. We have previously shown CPI-613 inhibits mitochondrial respiration, causes phosphorylation of PDH, activation of adenosine monophosphate activated kinase in acute… read more here.
Keywords: relapsed refractory; response; high dose; cpi 613 ... See more keywords
A multi-institution comparison of mitoxantrone, etoposide, and cytarabine (MEC) vs. high-dose cytarabine and mitoxantrone (Ara-C Couplets) therapy for patients with relapsed or refractory (R/R) acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e19005
Abstract: e19005Background: R/R AML has a poor prognosis, thus salvage chemotherapy is used as a bridge to HSCT, however the optimal regimen remains unknown. MEC is commonly used as salvage; ~ 66% of patient... read more here.
Keywords: institution comparison; mec; cytarabine; comparison mitoxantrone ... See more keywords