Drug testing for mitragynine and kratom: Analytical challenges and medico‐legal considerations
Sign Up to like & getrecommendations! Published in 2022 at "Drug Testing and Analysis"
DOI: 10.1002/dta.3391
Abstract: Abstract Mitragyna speciosa, known as kratom, is a tropical tree native to Southeast Asia that has long been used to increase energy and in traditional medicine. Kratom leaves contain several indole alkaloids including mitragynine, mitraciliatine,… read more here.
Keywords: testing mitragynine; mitragynine kratom; plant material; mitragynine ... See more keywords
Cross-reinstatement of mitragynine and morphine place preference in rats
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.113021
Abstract: Kratom is a medicinal plant that exhibits promising results as an opiate substitute. However, there is little information regarding the abuse profile of its main psychoactive constituent, mitragynine (MG), particularly in relapse to drug abuse.… read more here.
Keywords: cross reinstatement; morphine; mitragynine; place preference ... See more keywords
Metabolite and Molecular Characterization of Mitragyna speciosa Identifies Developmental and Genotypic Effects on Monoterpene Indole and Oxindole Alkaloid Composition.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.3c00092
Abstract: The monoterpene indole alkaloid (MIA) mitragynine has garnered attention as a potential treatment for pain, opioid use disorder, and opioid withdrawal because of its combined pharmacology at opioid and adrenergic receptors in humans. This alkaloid… read more here.
Keywords: mitragyna speciosa; speciosa; mitragyna; mitragynine ... See more keywords
Directed Biosynthesis of Mitragynine Stereoisomers
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13644
Abstract: Mitragyna speciosa (“Kratom”) is used as a natural remedy for pain and management of opioid dependence. The pharmacological properties of Kratom have been linked to a complex mixture of monoterpene indole alkaloids, most notably mitragynine.… read more here.
Keywords: biosynthesis mitragynine; mitragynine stereoisomers; mitragynine; directed biosynthesis ... See more keywords
Pharmacokinetics and Safety of Mitragynine in Beagle Dogs.
Sign Up to like & getrecommendations! Published in 2020 at "Planta medica"
DOI: 10.1055/a-1212-5475
Abstract: Mitragynine is the most abundant psychoactive alkaloid derived from the leaves of Mitragyna speciosa (kratom), a tropical plant indigenous to regions of Southeast Asia. Mitragynine displays a moderate affinity to opioid receptors, and kratom is… read more here.
Keywords: mitragynine beagle; mitragynine; beagle dogs; safety mitragynine ... See more keywords
Suspected Driving Under the Influence Case Involving Mitragynine.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of analytical toxicology"
DOI: 10.1093/jat/bky028
Abstract: Mitragynine is a novel psychoactive substance (NPS) that has emerged as a designer opioid being distributed on the street. Mitragynine, also known as kratom, has dose-dependent pharmacological effects and possesses both stimulant-like and sedative effects… read more here.
Keywords: driving influence; suspected driving; mitragynine; influence case ... See more keywords
Rate and extent of mitragynine and 7‐hydroxymitragynine blood–brain barrier transport and their intra‐brain distribution: the missing link in pharmacodynamic studies
Sign Up to like & getrecommendations! Published in 2018 at "Addiction Biology"
DOI: 10.1111/adb.12661
Abstract: Mitragyna speciosa is reported to be beneficial for the management of chronic pain and opioid withdrawal in the evolving opioid epidemic. Data on the blood–brain barrier (BBB) transport of mitragynine and 7‐hydroxymitragynine, the active compounds… read more here.
Keywords: extent; mitragynine; transport; mitragynine hydroxymitragynine ... See more keywords
The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15832
Abstract: Mitragynine, the major alkaloid in Mitragyna speciosa (kratom), is a partial agonist at the μ opioid receptor. CYP3A‐dependent oxidation of mitragynine yields the metabolite 7‐OH mitragynine, a more efficacious μ receptor agonist. While both mitragynine… read more here.
Keywords: respiratory depressant; depressant effects; mitragynine limited; mitragynine ... See more keywords
Inhibition of α-Glucosidase and Pancreatic Lipase Properties of Mitragyna speciosa (Korth.) Havil. (Kratom) Leaves
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DOI: 10.3390/nu14193909
Abstract: Kratom (Mitragyna speciosa (Korth.) Havil.) has been used to reduce blood sugar and lipid profiles in traditional medicine, and mitragynine is a major constituent in kratom leaves. Previous data on the blood sugar and lipid-altering… read more here.
Keywords: kratom; pancreatic lipase; glucosidase pancreatic; mitragynine ... See more keywords
Solid phase extraction method for determination of mitragynine in urine and its application to mitragynine excretion study in rats receiving caffeine
Sign Up to like & getrecommendations! Published in 2017 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v16i7.28
Abstract: Purpose: To develop a solid phase extraction (SPE) method that utilizes reverse-phase high performance liquid chromatography (RP-HPLC) to determine mitragynine (MG) in rat and human urine, and to investigate the influence of caffeine (CF) on… read more here.
Keywords: solid phase; mitragynine; phase extraction; method ... See more keywords
Determination of Mitragynine in Mitragyna speciosa Raw Materials and Finished Products by Liquid Chromatography with UV Detection: Single-Laboratory Validation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of AOAC International"
DOI: 10.5740/jaoacint.16-0220
Abstract: Mitragyna speciosa (kratom) is a tree indigenous to Southeast Asia, and its leaves are used in herbal formulations because they contain indole alkaloids mitragynine and 7-hydroxy (7-OH) mitragynine. An HPLC method was developed, optimized, and… read more here.
Keywords: validation; mitragyna speciosa; mitragynine; method ... See more keywords