Diversity-Oriented Synthesis of ERα Modulators via Mitsunobu Macrocyclization.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01239
Abstract: The diversity of cyclic peptides was expanded by elaborating Mitsunobu macrocyclization, tethering various hydroxy acid building blocks with different Nε-amine substituents. This new strategy was then applied in synthesizing peptidomimetic estrogen receptor modulator (PERM) analogs… read more here.
Keywords: oriented synthesis; diversity; mitsunobu macrocyclization; diversity oriented ... See more keywords