Combined kidney and hematopoeitic cell transplantation to induce mixed chimerism and tolerance
Sign Up to like & getrecommendations! Published in 2019 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-019-0603-4
Abstract: Based on preclinical studies, combined kidney and hematopoietic cell transplantation was performed on fully HLA matched and haplotype matched patients at the Stanford University Medical Center. The object of the studies was to induce mixed… read more here.
Keywords: mixed chimerism; tolerance; combined kidney; chimerism ... See more keywords
Addition of Anti-CD40 Monoclonal Antibody to Nonmyeloablative Conditioning With Belatacept Abrogated Allograft Tolerance Despite Induction of Mixed Chimerism
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DOI: 10.1097/tp.0000000000002417
Abstract: Background We recently reported anti-CD40 monoclonal antibody and rapamycin (aCD40/rapa) to be a reliable, nontoxic, immunosuppressive regimen for combined islet and kidney transplantation (CIKTx) in nonhuman primates. In the current study, we attempted to induce… read more here.
Keywords: allograft tolerance; monoclonal antibody; chimerism; mixed chimerism ... See more keywords
Tolerance of a Vascularized Composite Allograft Achieved in MHC Class-I-mismatch Swine via Mixed Chimerism
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DOI: 10.3389/fimmu.2022.829406
Abstract: Background Vascularized composite allografts (VCAs) allow reconstruction of devastating injuries and amputations, yet require lifelong immunosuppression that is associated with significant morbidity. Induction of immune tolerance of VCAs would permit widespread use of these procedures.… read more here.
Keywords: mhc class; class; mixed chimerism; mismatch ... See more keywords
Donor derived hematopoietic stem cell niche transplantation facilitates mixed chimerism mediated donor specific tolerance
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DOI: 10.3389/fimmu.2023.1093302
Abstract: Compelling experimental evidence confirms that the robustness and longevity of mixed chimerism (MC) relies on the persistence and availability of donor-derived hematopoietic stem cell (HSC) niches in recipients. Based on our prior work in rodent… read more here.
Keywords: mixed chimerism; tolerance; donor; hsc niches ... See more keywords
Low-Dose Decitabine Monotherapy Reverses Mixed Chimerism in Adult Patients After Allogeneic Hematopoietic Stem Cell Transplantation With Myeloablative Conditioning Regimen: A Pilot Phase II Study
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DOI: 10.3389/fmed.2021.627946
Abstract: T cell mixed chimerism (MC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with myeloablative conditioning for hematological malignancies may indicate engraftment failure or disease relapse. Immune modulation, such as donor lymphocyte infusion (DLI) or the… read more here.
Keywords: allo hsct; mixed chimerism; chimerism; cell ... See more keywords