Mixed genetic background better recapitulates developmental and psychiatric phenotypes and heterogeneity than inbred C57BL/6J mice
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DOI: 10.1038/s41598-025-26215-6
Abstract: Preclinical models of neurodevelopmental and psychiatric conditions often rely on inbred mouse strains like C57BL/6J (B6), which exhibit limited genetic and behavioral variability. This limitation hampers the modeling of phenotypic heterogeneity, characteristic of these conditions.… read more here.
Keywords: mice; variability; mixed genetic; behavioral variability ... See more keywords