An Angle on MK2 Inhibition—Optimization and Evaluation of Prevention of Activation Inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900303
Abstract: The mitogen‐activated protein kinase p38α pathway has been an attractive target for the treatment of inflammatory conditions such as rheumatoid arthritis. While a number of p38α inhibitors have been taken to the clinic, they have… read more here.
Keywords: prevention activation; activated protein; mk2; p38 ... See more keywords
Inhibition of MK2 suppresses IL‐1β, IL‐6, and TNF‐α‐dependent colorectal cancer growth
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31191
Abstract: Colorectal cancer (CRC) development and progression is associated with chronic inflammation. We have identified the MAPK‐activated protein kinase 2 (MK2) pathway as a primary mediator of inflammation in CRC. MK2 signaling promotes production of proinflammatory… read more here.
Keywords: colorectal cancer; inhibition; mk2; growth ... See more keywords
On Ramsey $$(mK_2,H)$$(mK2,H)-Minimal Graphs
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DOI: 10.1007/s00373-016-1748-1
Abstract: Let $$\mathcal {R}(G,H)$$R(G,H) denote the set of all graphs F satisfying $$F \rightarrow (G,H)$$F→(G,H) and for every $$e \in E(F),$$e∈E(F),$$(F-e) \nrightarrow (G,H).$$(F-e)↛(G,H). In this paper, we derive the necessary and sufficient conditions for graphs belonging… read more here.
Keywords: minimal graphs; graphs; mk2 minimal; mk2 ... See more keywords
Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP27.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2018.04.009
Abstract: The signaling axis of p38 mitogen-activated protein kinase (p38 MAPK) and MAPK-activated protein kinase 2 (MK2) is the dominant pathway that leads to heat shock protein 27 (HSP27) phosphorylation. After activation of MK2 by p38… read more here.
Keywords: p38 mapk; cell migration; mk2; p38 ... See more keywords
Activation of the MKK3-p38-MK2-ZFP36 Axis by Coronavirus Infection Restricts the Upregulation of AU-Rich Element-Containing Transcripts in Proinflammatory Responses
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.02086-21
Abstract: Excessive and uncontrolled induction and release of proinflammatory cytokines and chemokines, the so-called cytokine release syndrome (CRS), would cause life-threatening complications and multiple organ failure in severe coronavirus infections, including severe acute respiratory syndrome (SARS),… read more here.
Keywords: coronavirus; kinase; zfp36; coronavirus infection ... See more keywords
Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in NSCLC.
Sign Up to like & getrecommendations! Published in 2023 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00155.2022
Abstract: RATIONALE Non-small cell lung cancers (NSCLC) demonstrate intrinsic resistance to cell death, even after chemotherapy. Previous work suggested defective nuclear translocation of active caspase-3 in observed resistance to cell death. We have identified mitogen activated… read more here.
Keywords: tumor; survival; mk2 transcript; transcript levels ... See more keywords
Abstract 2690: MK2 pathway blockade inhibits inflammatory cytokine production and colorectal cancer growth and invasion
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-2690
Abstract: Introduction: Colorectal cancer is the third most common malignancy diagnosed for both men and women in the United States of America. High levels of inflammatory cytokines in colorectal tumors cause increased growth and invasion and… read more here.
Keywords: invasion; growth invasion; mk2; cancer ... See more keywords
Abstract 15314: Gene Therapy With Pellino1 Improves Perfusion and Decreases Tissue Loss in an Flk-1 Heterozygous Murine Limb Ischemia Model But Fails in Mapkapkinase 2 Knockout Mice
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.15314
Abstract: Introduction: Peripheral vascular disease (PVD) is a major cause of morbidity in the US. Vascular endothelial growth factor (VEGF) induces angiogenesis through Fetal-Liver Kinase-1 (Flk-1 or VEGFR-2), an endothelial tyrosine kinase receptor which activates a… read more here.
Keywords: flk; mice; ischemia; limb ... See more keywords
MK2 is a therapeutic target for high-risk multiple myeloma
Sign Up to like & getrecommendations! Published in 2018 at "Haematologica"
DOI: 10.3324/haematol.2017.182121
Abstract: Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by heterogeneous genetic diversity. Although the development of proteasome inhibitors and immumodulatory drugs combined with autologous stem cell transplantation (ASCT) have achieved advanced improvement for… read more here.
Keywords: high risk; mk2; multiple myeloma; expression ... See more keywords
MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.607891
Abstract: Chronic inflammation increases the risk for colorectal cancer through a variety of mechanisms involving the tumor microenvironment. MAPK-activated protein kinase 2 (MK2), a major effector of the p38 MAPK stress and DNA damage response signaling… read more here.
Keywords: angiogenesis; inflammation; colon; mk2 ... See more keywords
Targeting MK2 Is a Novel Approach to Interfere in Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00722
Abstract: MAPKAPK2 (MK2), the direct substrate of p38 MAPK, has been well-acknowledged as an attractive drug target for cancer therapy. However, few studies have assessed the functions of it in multiple myeloma (MM). In the present… read more here.
Keywords: novel approach; mk2; multiple myeloma; mk2 novel ... See more keywords