TLK1‐mediated MK5‐S354 phosphorylation drives prostate cancer cell motility and may signify distinct pathologies
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13183
Abstract: Metastases account for the majority of prostate cancer (PCa) deaths, and targeting them is a major goal of systemic therapy. We identified a novel interaction between two kinases: tousled‐like kinase 1 (TLK1) and MAP kinase‐activated… read more here.
Keywords: tlk1 mk5; prostate cancer; mk5; motility ... See more keywords
MK5: A novel regulator of cardiac fibroblast function?
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DOI: 10.1002/iub.1677
Abstract: MAP kinase‐activated protein kinases (MKs), protein serine/threonine kinases downstream of the MAPKs, regulate a number of biological functions. MK5 was initially identified as a substrate for p38 MAPK but subsequent studies revealed that MK5 activity… read more here.
Keywords: function mk5; novel regulator; mk5 novel; cardiac ... See more keywords
Abstract 518: Phosphorylation of MK5 at Threonine-182 in the Activation Loop is Mediated by P38α/β in Cardiac Fibroblasts
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DOI: 10.1161/res.127.suppl_1.518
Abstract: MAP kinase-activated protein kinase-5 (MK5) is a protein serine/threonine kinase involved in fibroblast function. MK5 is activated by phosphorylation at threonine-182 (Thr182): p38α/β, ERK3, and ERK4 have been implicated. We examined the phosphorylation of MK5… read more here.
Keywords: phosphorylation mk5; threonine 182; immunoreactivity; phos tag ... See more keywords
The TLK1–MK5 Axis Regulates Motility, Invasion, and Metastasis of Prostate Cancer Cells
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DOI: 10.3390/cancers14235728
Abstract: Background Metastatic dissemination of prostate cancer (PCa) accounts for majority of PCa related deaths. However, the exact mechanism of PCa cell spread is still unknown. We uncovered a novel interaction between two unrelated promotility factors,… read more here.
Keywords: metastasis; tlk1 mk5; mk5; pca ... See more keywords