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   Articles with "mkk4" as a keyword



Crocin Attenuates Nrf2/GPX4 Mediated Ferroptosis in Obstructive Nephropathy by Selectively Targeting MKK4

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recommendations! Published in 2025 at "Phytotherapy Research"

DOI: 10.1002/ptr.70092

Abstract: Renal fibrosis is a critical pathogenesis of chronic kidney disease (CKD). Crocin, an active compound derived from saffron ( Crocus sativus L.), exhibits potent antioxidant and renal protection properties. However, the effects of crocin on… read more here.

Keywords: crocin; mkk4; renal fibrosis; ferroptosis ... See more keywords

Prenylated quinolinecarboxylic acid derivative prevents neuronal cell death through inhibition of MKK4

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recommendations! Published in 2019 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2018.10.008

Abstract: &NA; The development of neuroprotective agents is necessary for the treatment of neurodegenerative diseases. Here, we report PQA‐11, a prenylated quinolinecarboxylic acid (PQA) derivative, as a potent neuroprotectant. PQA‐11 inhibits glutamate‐induced cell death and caspase‐3… read more here.

Keywords: prenylated quinolinecarboxylic; pqa; mkk4; cell death ... See more keywords
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Discovery of Covalent MKK4/7 Dual Inhibitor.

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recommendations! Published in 2020 at "Cell chemical biology"

DOI: 10.1016/j.chembiol.2020.08.014

Abstract: MKK4/7 are kinases that phosphorylate JNKs and regulate the MAPK signaling pathway. Their overexpression has been associated with tumorigenesis and aggressiveness in cancers such as breast, prostate, non-small cell lung, and pediatric leukemia, making them… read more here.

Keywords: inhibitor; bsj 122; discovery covalent; mkk4 ... See more keywords

Clinicopathological and prognostic significance of MKK4 and MKK7 in resectable pancreatic ductal adenocarcinoma.

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recommendations! Published in 2019 at "Human pathology"

DOI: 10.1016/j.humpath.2018.11.026

Abstract: Mitogen-activated protein kinase kinase 4 (MKK4) and mitogen-activated protein kinase kinase 7 (MKK7) were shown to regulate biological behavior in many malignancies. In pancreatic ductal adenocarcinoma (PDAC), it remains controversial whether MKK4 and MKK7 have… read more here.

Keywords: pancreatic ductal; mkk4 mkk7; mkk4 expression; mkk4 ... See more keywords