Prenylated quinolinecarboxylic acid derivative prevents neuronal cell death through inhibition of MKK4
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.10.008
Abstract: &NA; The development of neuroprotective agents is necessary for the treatment of neurodegenerative diseases. Here, we report PQA‐11, a prenylated quinolinecarboxylic acid (PQA) derivative, as a potent neuroprotectant. PQA‐11 inhibits glutamate‐induced cell death and caspase‐3… read more here.
Keywords: prenylated quinolinecarboxylic; pqa; mkk4; cell death ... See more keywords
Discovery of Covalent MKK4/7 Dual Inhibitor.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.08.014
Abstract: MKK4/7 are kinases that phosphorylate JNKs and regulate the MAPK signaling pathway. Their overexpression has been associated with tumorigenesis and aggressiveness in cancers such as breast, prostate, non-small cell lung, and pediatric leukemia, making them… read more here.
Keywords: inhibitor; bsj 122; discovery covalent; mkk4 ... See more keywords
Clinicopathological and prognostic significance of MKK4 and MKK7 in resectable pancreatic ductal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Human pathology"
DOI: 10.1016/j.humpath.2018.11.026
Abstract: Mitogen-activated protein kinase kinase 4 (MKK4) and mitogen-activated protein kinase kinase 7 (MKK7) were shown to regulate biological behavior in many malignancies. In pancreatic ductal adenocarcinoma (PDAC), it remains controversial whether MKK4 and MKK7 have… read more here.
Keywords: pancreatic ductal; mkk4 mkk7; mkk4 expression; mkk4 ... See more keywords