MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.101903
Abstract: Abdominal aortic aneurysm (AAA) is a catastrophic disease with little effective therapy. Myocardin related transcription factor A (MRTFA, MKL1) is a multifaceted transcription factor, regulating diverse biological processes. However, a detailed understanding of the mechanistic… read more here.
Keywords: senescence; aortic aneurysm; aaa formation; abdominal aortic ... See more keywords
MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00301-w
Abstract: Macrophage-dependent inflammatory response is considered a pivotal biological process that contributes to a host of diseases when aberrantly activated. The underlying epigenetic mechanism is not completely understood. We report here that MKL1 was both sufficient… read more here.
Keywords: dependent inflammatory; mkl1; inflammatory response; landscape dependent ... See more keywords
Response by Li and Xu to Letter Regarding Article, "Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury".
Sign Up to like & getrecommendations! Published in 2019 at "Circulation"
DOI: 10.1161/circulationaha.119.040160
Abstract: May 14, 2019 e965 Zilong Li, BS Yong Xu, PhD In Response: We thank Dr Wang for his letter concerning our recently published article1 and appreciate the opportunity to respond to his comments. We agree… read more here.
Keywords: reperfusion injury; ischemia reperfusion; reperfusion; injury ... See more keywords
SRF and MKL1 Independently Inhibit Brown Adipogenesis
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0170643
Abstract: Active brown adipose tissue is responsible for non-shivering thermogenesis in mammals which affects energy homeostasis. The molecular mechanisms underlying this activation as well as the formation and activation of brite adipocytes have gained increasing interest… read more here.
Keywords: independently inhibit; mkl1 independently; brown adipogenesis; mkl1 ... See more keywords
Resident Fibroblast MKL1 Is Sufficient to Drive Pro-fibrogenic Response in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.812748
Abstract: Fibrosis is an evolutionarily conserved pathophysiological process serving bifurcated purposes. On the one hand, fibrosis is essential for wound healing and contributes to the preservation of organ function. On the other hand, aberrant fibrogenic response… read more here.
Keywords: pro fibrogenic; mkl1; resident fibroblast; mice ... See more keywords
Suppression of MKL1 promotes adipocytic differentiation and reduces the proliferation of myxoid liposarcoma cells.
Sign Up to like & getrecommendations! Published in 2020 at "Oncology letters"
DOI: 10.3892/ol.2020.12232
Abstract: Myxoid liposarcoma (MLS) is thought to occur due to defective adipocytic differentiation in mesenchymal stem cells. A promising strategy for MLS treatment is the prevention of sarcomagenesis by promoting the terminal differentiation of MLS cells… read more here.
Keywords: suppression; mls; mls cells; adipocytic differentiation ... See more keywords