MKLP2 functions in early mitosis to ensure proper chromosome congression.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.259560
Abstract: Mitotic kinesin-like protein 2 (MKLP2) is a motor protein with a well-established function in promoting cytokinesis. However, our results with siRNAs targeting MKLP2 and small molecule inhibitors of MKLP2 (MKLP2i) suggested a function earlier in… read more here.
Keywords: mklp2 functions; mklp2; chromosome congression; mitosis ... See more keywords
The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry
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DOI: 10.7554/elife.27793
Abstract: MKLP2, a kinesin-6, has critical roles during the metaphase-anaphase transition and cytokinesis. Its motor domain contains conserved nucleotide binding motifs, but is divergent in sequence (~35% identity) and size (~40% larger) compared to other kinesins.… read more here.
Keywords: divergent mitotic; mklp2; mitotic kinesin; motor ... See more keywords