Stress-Induced Epigenetic Changes in Hippocampal Mkp-1 Promote Persistent Depressive Behaviors
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01689-4
Abstract: Chronic stress induces persistent depressive behaviors. Stress-induced transcriptional alteration over the homeostatic range in stress hormone–sensitive brain regions is believed to underlie long-lasting depressive behaviors. However, the detailed mechanisms by which chronic stress causes those… read more here.
Keywords: hdac2 suv39h1; chronic stress; mkp; depressive behaviors ... See more keywords
Downregulation of microsomal prostaglandin E synthase-1 (mPGES-1) expression in chondrocytes is regulated by MAP kinase phosphatase-1 (MKP-1).
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.03.014
Abstract: OBJECTIVES Microsomal prostaglandin E synthase-1 (mPGES-1) catalyses the formation of PGE2 in inflammatory tissues. It is considered a potential drug target in inflammatory conditions to achieve clinical benefits comparable to NSAIDs with a better tolerability.… read more here.
Keywords: microsomal prostaglandin; mkp; expression; mpges expression ... See more keywords
Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.08.067
Abstract: The mitogen-activated kinase phosphatase-3 (MKP-3) has gained great importance in the scientific community by acting as a regulator of the cell cycle through dephosphorylation of FoxO1, an important transcription factor involved in the insulin intracellular… read more here.
Keywords: mkp; kinase phosphatase; hypothalamus; foxo1 phosphorylation ... See more keywords
MKP-1 is required to limit myeloid-cell mediated oral squamous cell carcinoma progression and regional extension.
Sign Up to like & getrecommendations! Published in 2021 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2021.105401
Abstract: Mitogen-activated protein kinases (MAPKs) require MAPK phosphatases (MKPs) for deactivation of MAPK intracellular signaling. MKP-1 (encoded by Dusp1) is a key negative regulator of MAPKs and prior reports have indicated that MKP-1 regulates oral cancer-associated… read more here.
Keywords: mkp; oral squamous; mice; myeloid ... See more keywords
MKP-1 negative regulates Staphylococcus aureus induced inflammatory responses in Raw264.7 cells: roles of PKA-MKP-1 pathway and enhanced by rolipram
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10187-3
Abstract: MAP phosphatases (MKP)-1 acts as an important regulator of innate immune response through a mechanism of control and attention both MAPK and NF-κB molecules during bacterial infection. However, the regulatory role of MKP-1 in the… read more here.
Keywords: mkp pathway; mkp; pka mkp; negative regulates ... See more keywords
Mitigation of salt stress on tomato crop by using foliar spraying or fertigation of various products
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Plant Nutrition"
DOI: 10.1080/01904167.2020.1771587
Abstract: Abstract Among major constraints to crop production, salt stress affects the morphological structure and yield in crop plants. Nano-fertilizers, have made their hierarchy to supplement the traditional fertilizers in mitigating the effect of abiotic stress… read more here.
Keywords: mkp; salt; stress; foliar spraying ... See more keywords
Exendin-4, a Glucagon-Like Peptide-1 Receptor Agonist, Attenuates Prostate Cancer Cell Proliferation via Phosphorylation of MKP-1
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-1957-p
Abstract: Pleiotropic benefits of incretin therapy beyond glycemic control have been reported and receiving much attention. Cancer is one of major causes of death in patients with type 2 diabetes. We have previously reported Exendin-4(Ex-4), a… read more here.
Keywords: mkp; attenuates prostate; prostate cancer; cancer cell ... See more keywords
MKP-5 Relieves Lipotoxicity-Induced Islet β-Cell Dysfunction and Apoptosis via Regulation of Autophagy
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21197161
Abstract: Mitogen-activated protein kinase phosphatase-5 (MKP-5) is a regulator of extracellular signaling that is known to regulate lipid metabolism. In this study, we found that obesity caused by a high-fat diet (HFD) decreased the expression of… read more here.
Keywords: mkp; apoptosis; lipotoxicity; islet ... See more keywords
Metabolic Impact of MKP-2 Upregulation in Obesity Promotes Insulin Resistance and Fatty Liver Disease
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14122475
Abstract: The mechanisms connecting obesity with type 2 diabetes, insulin resistance, nonalcoholic fatty liver disease, and cardiovascular diseases remain incompletely understood. The function of MAPK phosphatase-2 (MKP-2), a type 1 dual-specific phosphatase (DUSP) in whole-body metabolism,… read more here.
Keywords: fatty liver; insulin resistance; mkp; obesity ... See more keywords
Overexpression of mitogen-activated protein kinase phosphatase-1 in endothelial cells reduces blood-brain barrier injury in a mouse model of ischemic stroke
Sign Up to like & getrecommendations! Published in 2023 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.363836
Abstract: Ischemic stroke can cause blood-brain barrier (BBB) injury, which worsens brain damage induced by stroke. Abnormal expression of tight junction proteins in endothelial cells (ECs) can increase intracellular space and BBB leakage. Selective inhibition of… read more here.
Keywords: brain; kinase; mkp; injury ... See more keywords