In vitro ubiquitination of Mycobacterium tuberculosis by E3 ubiquitin ligase, MKRN1
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Letters"
DOI: 10.1007/s10529-020-02873-6
Abstract: Ubiquitination has a role as a host defense mechanism against pathogens. To channelize autophagic mycobacteria to destruction, ubiquitin ligase like, Makorin Ring Finger Protein 1 (MKRN1) was speculated to play a role in ubiquitinating M.… read more here.
Keywords: ubiquitin ligase; mkrn1; tuberculosis; role ... See more keywords
Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/β-catenin signaling
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DOI: 10.1038/s41388-018-0267-3
Abstract: The adenomatous polyposis coli (APC) protein has a tumor-suppressor function by acting as a negative regulator of the Wnt signaling pathway. While its role as a tumor suppressor is well-defined, the post-translational modifications that regulate… read more here.
Keywords: catenin; polyposis coli; mkrn1; adenomatous polyposis ... See more keywords
Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation
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DOI: 10.1371/journal.pgen.1008581
Abstract: Makorins are evolutionary conserved proteins that contain C3H-type zinc finger modules and a RING E3 ubiquitin ligase domain. In Drosophila, maternal Makorin 1 (Mkrn1) has been linked to embryonic patterning but the mechanism remained unsolved.… read more here.
Keywords: embryonic patterning; patterning alleviating; mkrn1; translation ... See more keywords
Host MKRN1-Mediated Mycobacterial PPE Protein Ubiquitination Suppresses Innate Immune Response
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.880315
Abstract: Mycobacterium tuberculosis (Mtb), as an important intracellular pathogen, can invade and survive in macrophages and is capable of escaping the clearance of immune system. Despite decades of research efforts, the precise mechanism of immune escape… read more here.
Keywords: mycobacterial ppe; ppe protein; mkrn1; host mkrn1 ... See more keywords