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   Articles with "mks" as a keyword



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Thrombopoietic effects of CCAAT/enhancer-binding protein β on the early-stage differentiation of megakaryocytes.

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recommendations! Published in 2021 at "Archives of biochemistry and biophysics"

DOI: 10.1016/j.abb.2021.108846

Abstract: CCAAT/enhancer-binding protein β (C/EBPβ) is a transcription factor that is involved in adipocytic and monocytic differentiation. However, the physiological role of C/EBPβ in megakaryocytes (MKs) is not clear. In this study, we investigated the effects… read more here.

Keywords: ccaat enhancer; enhancer binding; differentiation; binding protein ... See more keywords
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Megakaryocyte-stromal cell interactions: effect on megakaryocyte proliferation, proplatelet production, and survival.

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recommendations! Published in 2022 at "Experimental hematology"

DOI: 10.1016/j.exphem.2022.01.002

Abstract: Bone marrow stromal cells provide a proper environment for the development of hematologic lineages. The incorporation of different stromal cells to in vitro culture systems would be an attractive model to study megakaryopoiesis and thrombopoiesis. Our… read more here.

Keywords: survival; megakaryocyte; stromal cell; mks ... See more keywords
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Modulation of megakaryopoiesis and platelet production during inflammation.

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recommendations! Published in 2019 at "Thrombosis research"

DOI: 10.1016/j.thromres.2019.05.008

Abstract: Megakaryocytes (MKs) are widely known as the progenitor cells of platelets. These large, polyploid cells are a derivative of the hematopoietic stem cell (HSC), and reside in the bone marrow, lining blood vessel walls where… read more here.

Keywords: modulation megakaryopoiesis; inflammation; platelet production; platelet ... See more keywords
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Large-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-28459-x

Abstract: Megakaryocytes (MKs) are the precursors of platelets (PLTs) and may be used for PLT production in vivo or in vitro, as well as a source for PLT-derived growth factors. Induced pluripotent stem cells represent an… read more here.

Keywords: large scale; production megakaryocytes; megakaryocytes microcarrier; production ... See more keywords
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Developmental differences of in vitro cultured murine bone marrow- and fetal liver-derived megakaryocytes.

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recommendations! Published in 2021 at "Platelets"

DOI: 10.1080/09537104.2021.2007869

Abstract: Multiple lines of evidence support differences in the megakaryopoiesis during development. Murine in vitro models to study megakaryopoiesis employ cultured megakaryocytes MKs derived from adult bone marrow (BM) or fetal livers (FL) of mouse embryos.… read more here.

Keywords: size; mks; marrow fetal; bone marrow ... See more keywords
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Inhibition of Megakaryocyte Differentiation by Antibody–Drug Conjugates (ADCs) is Mediated by Macropinocytosis: Implications for ADC-induced Thrombocytopenia

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recommendations! Published in 2017 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1535-7163.mct-16-0710

Abstract: Thrombocytopenia is a common adverse event in cancer patients treated with antibody–drug conjugates (ADC), including AGS-16C3F, an ADC targeting ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase-3) and trastuzumab emtansine (T-DM1). This study aims to elucidate the mechanism of action… read more here.

Keywords: adc induced; macropinocytosis; mks; induced thrombocytopenia ... See more keywords
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A Single-Cell Approach to Unraveling Abnormal Megakaryocyte Differentiation and Function in Myelofibrosis

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recommendations! Published in 2017 at "Blood"

DOI: 10.1182/blood.v130.suppl_1.490.490

Abstract: Increased numbers of immature/low ploidy MKs are a hallmark feature of myelofibrosis (MF). MF MKs produce pathological amounts of pro-fibrotic factors including TGFβ causing a severe bone marrow (BM) fibrosis. Isolating MKs in MF is… read more here.

Keywords: single cell; cell approach; hspcs; cell ... See more keywords
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Occurrence and role of lung megakaryocytes in infection and inflammation

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.1029223

Abstract: Megakaryocytes (MKs) are large cells giving rise to platelets. It is well established that in adults, MKs develop from hematopoietic stem cells and reside in the bone marrow. MKs are also rare but normal constituents… read more here.

Keywords: lung; mks; bone marrow; occurrence role ... See more keywords
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Megakaryocyte Diversity in Ontogeny, Functions and Cell-Cell Interactions

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recommendations! Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.840044

Abstract: Hematopoietic stem cells (HSCs) rely on local interactions in the bone marrow (BM) microenvironment with stromal cells and other hematopoietic cells that facilitate their survival and proliferation, and also regulate their functions. HSCs and multipotent… read more here.

Keywords: ontogeny functions; functions cell; diversity ontogeny; cell interactions ... See more keywords