Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease
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DOI: 10.1136/gutjnl-2021-326534
Abstract: Objective Intestinal barrier loss is a Crohn’s disease (CD) risk factor. This may be related to increased expression and enzymatic activation of myosin light chain kinase 1 (MLCK1), which increases intestinal paracellular permeability and correlates… read more here.
Keywords: disease; barrier loss; mlck1; fkbp8 ... See more keywords
Finding a mate for MLCK: improving the potential for therapeutic targeting of gut permeability
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DOI: 10.1136/gutjnl-2022-327599
Abstract: Elevated intestinal permeability has long been appreciated as a pathophysiological marker of gut inflammatory disease, in particular in inflammatory bowel disease (IBD). In addition to the association of IBD risk genetic variants with multiple aspects… read more here.
Keywords: gut; disease; mlck; permeability ... See more keywords