A modified screening strategy for Lynch syndrome among MLH1-deficient CRCs: Analysis from consecutive Chinese patients in a single center
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101049
Abstract: Highlights • We comprehensively analyzed both BRAF mutation status and MLH1 promoter methylation status in MLH1-deficient patients from a large consecutive CRC cohort, which may help to modify strategy of LS screening for Chinese MLH1-deficient… read more here.
Keywords: modified screening; deficient; mlh1 deficient; deficient crcs ... See more keywords
Targeting mitochondrial DNA polymerase gamma for selective inhibition of MLH1 deficient colon cancer growth
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0268391
Abstract: Synthetic lethality in DNA repair pathways is an important strategy for the selective treatment of cancer cells without harming healthy cells and developing cancer-specific drugs. The synthetic lethal interaction between the mismatch repair (MMR) protein,… read more here.
Keywords: dna; growth; mlh1 deficient; deficient ... See more keywords