BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations
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DOI: 10.18632/oncotarget.18098
Abstract: Deficient mismatch repair (MMR) and microsatellite instability (MSI) contribute to ~15% of colorectal cancer (CRCs). We hypothesized MSI leads to mutations in DNA repair proteins including BRCA2 and cancer drivers including EGFR. We analyzed mutations… read more here.
Keywords: mismatch repair; crcs; msh2 mlh1; mlh1 mutant ... See more keywords