Concurrent loss of MLH1, PMS2 and MSH6 immunoexpression in digestive system cancers indicating a widespread dysregulation in DNA repair processes
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DOI: 10.3389/fonc.2022.1019798
Abstract: Immunohistochemical analysis of mismatch repair (MMR) protein expression is widely used to identify tumors with a deficient MMR (dMMR). MMR proteins (MLH1/PMS2 and MSH2/MSH6) work as functional heterodimers, which usually leads to the loss of… read more here.
Keywords: msh6; mlh1 pms2; pms2 msh6; repair ... See more keywords