Mitochondrial DNA damage in diabetic retinopathy: role of epigenetics
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.369
Abstract: Purpose Diabetes dysfunctions retinal mitochondria and increases base pair mismatches in mitochondrial DNA (mtDNA), and damaged mtDNA impairs the electron transport chain system. A mismatch repair system actively repairs the uncomplimentary base pairs, but in… read more here.
Keywords: diabetic retinopathy; dna; mlh1 promoter; damage ... See more keywords
A systematic review and meta-analysis approach on diagnostic value of MLH1 promoter methylation for head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000017651
Abstract: Abstract Background: Head and neck squamous cell carcinoma (HNSCC) is the leading histological type among head and neck cancers. Several studies have explored an association between aberrant methylation of MutL homolog-1 (MLH1) promoter and HNSCC… read more here.
Keywords: mlh1 promoter; methylation; promoter methylation; meta analysis ... See more keywords
Epigenetic Silencing of the MLH1 Promoter in Relation to the Development of Gastric Cancer and its use as a Biomarker for Patients with Microsatellite Instability: a Systematic Analysis
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000486354
Abstract: Background/Aims: Human mutL homolog 1 (MLH1) promoter methylation was reported in gastric cancer (GC). This study determined the clinicopathological, prognostic, and diagnostic effects of MLH1 promoter methylation in GC. Methods: The combined odds ratio (OR)… read more here.
Keywords: mlh1 promoter; promoter methylation; gastric cancer; promoter ... See more keywords
Lynch syndrome-associated endometrial carcinoma with MLH1 germline mutation and MLH1 promoter hypermethylation: a case report and literature review
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DOI: 10.1186/s12885-018-4489-0
Abstract: BackgroundLynch syndrome is an autosomal dominant inherited disease caused by germline mutations in mismatch repair genes. Analysis for microsatellite instability (MSI) and immunohistochemistry (IHC) of protein expressions of disease-associated genes is used to screen for… read more here.
Keywords: mlh1; mlh1 promoter; endometrial cancer; cancer ... See more keywords
Amplicon-based NGS test for assessing MLH1 promoter methylation and its correlation with BRAF mutation in colorectal cancer patients.
Sign Up to like & getrecommendations! Published in 2023 at "Experimental and molecular pathology"
DOI: 10.2139/ssrn.4135046
Abstract: Detecting MLH1 promoter methylation is highly relevant to differentiate between possible Lynch syndrome patients or patients with sporadic causes of MLH1/PMS2 deficiency in colorectal (CRC) and endometrial cancers. Here, we aimed to develop a test… read more here.
Keywords: methylation; braf; test; mlh1 ... See more keywords
Prognostic value of MLH1 promoter methylation in male patients with esophageal squamous cell carcinoma.
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DOI: 10.3892/ol.2017.5759
Abstract: The DNA mismatch repair (MMR) gene MutL homolog 1 (MLH1) is critical for the maintenance of genomic integrity. Methylation of the MLH1 gene promoter was identified as a prognostic marker for numerous types of cancer… read more here.
Keywords: mlh1 promoter; promoter methylation; male patients; promoter ... See more keywords