Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging
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DOI: 10.1038/s41467-021-25028-1
Abstract: Embryonic aneuploidy from mis-segregation of chromosomes during meiosis causes pregnancy loss. Proper disjunction of homologous chromosomes requires the mismatch repair (MMR) genes MLH1 and MLH3, essential in mice for fertility. Variants in these genes can… read more here.
Keywords: human mlh1; variants causing; mlh1 variants; pregnancy loss ... See more keywords