GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one
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DOI: 10.1093/nar/gky143
Abstract: Abstract DNA repeat expansion underlies dozens of progressive neurodegenerative disorders. While the mechanisms driving repeat expansion are not fully understood, increasing evidence suggests a central role for DNA mismatch repair. The mismatch repair recognition complex… read more here.
Keywords: repeat expansion; mlh3 isoform; gaa ttc; expansion ... See more keywords