Mixed lineage kinase domain-like pseudokinase-mediated necroptosis aggravates periodontitis progression.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular medicine"
DOI: 10.1007/s00109-021-02126-7
Abstract: Necroptosis is a form of cell death that is reportedly involved in the pathogenesis of periodontitis. The role of Mlkl-involved necroptosis remains unclear. Herein, this project aimed to explore the role of MLKL-mediated necroptosis in… read more here.
Keywords: necroptosis aggravates; mlkl; mediated necroptosis; necroptosis ... See more keywords
MLKL contributes to shikonin-induced glioma cell necroptosis via promotion of chromatinolysis.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.09.007
Abstract: Chromatinolysis refers to enzymatic degradation of nuclear DNA and is regarded as one of the crucial events leading to cell death. Mixed-lineage kinase domain-like protein (MLKL) has been identified as a key executor of necroptosis,… read more here.
Keywords: chromatinolysis; glioma; mlkl; shikonin induced ... See more keywords
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.03.020
Abstract: The activation of mixed lineage kinase-like (MLKL) by receptor-interacting protein kinase-3 (RIPK3) results in plasma membrane (PM) disruption and a form of regulated necrosis, called necroptosis. Here, we show that, during necroptosis, MLKL-dependent calcium (Ca2+) influx… read more here.
Keywords: escrt iii; mlkl; cell death; necroptotic cell ... See more keywords
FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.04.002
Abstract: Pathways controlling intestinal epithelial cell (IEC) death regulate gut immune homeostasis and contribute to the pathogenesis of inflammatory bowel diseases. Here, we show that caspase-8 and its adapter FADD act in IECs to regulate intestinal… read more here.
Keywords: caspase; death; intestinal epithelial; mlkl ... See more keywords
Single-Molecule Monitoring of Membrane Association of the Necroptosis Executioner MLKL with Discernible Anchoring and Insertion Dynamics.
Sign Up to like & getrecommendations! Published in 2023 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c05062
Abstract: The dynamics of membrane proteins that are well-folded in water and become functional after self-insertion into cell membranes is not well understood. Herein we report on single-molecule monitoring of membrane association dynamics of the necroptosis… read more here.
Keywords: membrane association; single molecule; molecule monitoring; mlkl ... See more keywords
A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00742-x
Abstract: Necroptosis is a lytic, inflammatory cell death pathway that is dysregulated in many human pathologies. The pathway is executed by a core machinery comprising the RIPK1 and RIPK3 kinases, which assemble into necrosomes in the… read more here.
Keywords: ripk3 mlkl; microscopy; mlkl; ripk1 ripk3 ... See more keywords
Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-021-00924-7
Abstract: Phosphorylation of the pseudokinase mixed lineage kinase domain-like protein (MLKL) by the protein kinase RIPK3 targets MLKL to the cell membrane, where it triggers necroptotic cell death. We report that conjugation of K63-linked polyubiquitin chains… read more here.
Keywords: site specific; ubiquitination mlkl; cell death; mlkl ... See more keywords
Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05979-8
Abstract: Cancer immunotherapy can induce durable antitumor responses. However, many patients poorly respond to such therapies. Here we describe a generic antitumor therapy that is based on the intratumor delivery of mRNA that codes for the… read more here.
Keywords: treatment; mlkl; necroptosis; mrna treatment ... See more keywords
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-27032-x
Abstract: The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However, the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in targeting the pathway therapeutically. This mode of… read more here.
Keywords: mlkl; necroptosis; human ripk3; ripk3 ... See more keywords
Epigenetic silencing of RIPK3 in hepatocytes prevents MLKL-mediated necroptosis from contributing to liver pathologies.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.08.040
Abstract: BACKGROUND AND AIMS Necroptosis is a highly inflammatory mode of cell death that has been implicated in causing hepatic injury including steatohepatitis/NASH. However, the evidence supporting these claims has been controversial. A comprehensive, fundamental understanding… read more here.
Keywords: necroptosis; silencing ripk3; mlkl; pathology ... See more keywords
The molecular mechanisms of MLKL-dependent and MLKL-independent necrosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjaa055
Abstract: Abstract Necrosis, a type of unwanted and passive cell demise, usually occurs under the excessive external stress and is considered to be unregulated. However, under some special conditions such as caspase inhibition, necrosis is regulable… read more here.
Keywords: necrosis; mechanisms mlkl; mlkl; dependent mlkl ... See more keywords