MiR‐27a downregulates 14‐3‐3θ, RUNX1, AF4, and MLL‐AF4, crucial drivers of blast transformation in t(4;11) leukemia cells
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DOI: 10.1002/cbf.3736
Abstract: The chromosomal translocation t(4;11)(q21;q23), a hallmark of an aggressive form of acute lymphoblastic leukemia (ALL), encodes mixed‐lineage leukemia (MLL)‐AF4 oncogenic chimera that triggers aberrant transcription of genes involved in lymphocyte differentiation, including HOXA9 and MEIS1.… read more here.
Keywords: af4 mll; mir 27a; mll af4; leukemia ... See more keywords
MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia
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DOI: 10.1016/j.celrep.2016.12.054
Abstract: Summary Understanding the underlying molecular mechanisms of defined cancers is crucial for effective personalized therapies. Translocations of the mixed-lineage leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic pathways and cause poor-prognosis… read more here.
Keywords: mll af4; af4 spreading; sensitivity; gene ... See more keywords
Antileukemic Efficacy of BET Inhibitor in a Preclinical Mouse Model of MLL-AF4+ Infant ALL
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DOI: 10.1158/1535-7163.mct-17-1123
Abstract: MLL-rearranged acute lymphoblastic leukemia (ALL) occurring in infants is a rare but very aggressive leukemia, typically associated with a dismal prognosis. Despite the development of specific therapeutic protocols, infant patients with MLL-rearranged ALL still suffer… read more here.
Keywords: mll af4; model mll; mouse model; mll rearranged ... See more keywords
Abstract 4937: Immunoproteasome inhibitors for the treatment of t(4;11)-driven ALL
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4937
Abstract: The t(4;11)(q21;q23) chromosomal translocation that creates the MLL-AF4 fusion protein, confers a poor prognosis in infant acute lymphoblastic leukemia (ALL). This translocation also sensitizes cells to proteasome inhibitors bortezomib and carfilzomib, which are approved by… read more here.
Keywords: abstract 4937; mll af4; treatment driven; inhibitors treatment ... See more keywords
The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitment.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-04-777185
Abstract: Chromosome rearrangements involving the mixed-lineage leukemia gene (MLL) create MLL-fusion proteins, which could drive both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The lineage decision of MLL-fusion leukemia is influenced by the fusion… read more here.
Keywords: mll af4; af4 interlinked; lineage; fusion ... See more keywords
Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions
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DOI: 10.3324/haematol.2018.202044
Abstract: The t(4;11)(q21;q23) translocation is associated with high-risk infant pro-B-cell acute lymphoblastic leukemia and arises prenatally during embryonic/fetal hematopoiesis. The developmental/pathogenic contribution of the t(4;11)-resulting MLL-AF4 (MA4) and AF4-MLL (A4M) fusions remains unclear; MA4 is always… read more here.
Keywords: mll af4; differentiation; fusion; hemato endothelial ... See more keywords