Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.11.039
Abstract: Background Chromosomal translocation-induced expression of the chromatin modifying oncofusion protein MLL-AF9 promotes acute myelocytic leukemia (AML). Whereas WNT/β-catenin signaling has previously been shown to support MLL-AF9-driven leukemogenesis, the mechanism underlying this relationship remains unclear. Methods… read more here.
Keywords: oncofusion protein; six1; wnt; mll af9 ... See more keywords
Absence of the Shb gene in mixed-lineage leukemia MLL-AF9 cells increases latency in mice despite higher proliferation rates in vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112368
Abstract: Mixed lineage leukemia (MLL) arises from several KMT2A-gene chromosomal translocations. Shb gene deficiency has been found to exhibit pleiotropic effects in different models of leukemia, and consequently, this study aimed to investigate MLL-AF9-induced leukemia in… read more here.
Keywords: af9 cells; mll af9; leukemia; gene ... See more keywords
Protease-activated receptor-1 inhibits proliferation but enhances leukemia stem cell activity in acute myeloid leukemia
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DOI: 10.1038/onc.2016.416
Abstract: Eradication of leukemia stem cells (LSCs) is the ultimate goal of treating acute myeloid leukemia (AML). We recently showed that the combined loss of Runx1/Cbfb inhibited the development of MLL-AF9-induced AML. However, c-Kit+/Gr-1− cells remained… read more here.
Keywords: par; mll af9; receptor; leukemia ... See more keywords
Decreased cell stiffness enhances leukemia development and progression
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DOI: 10.1038/s41375-020-0763-7
Abstract: Emerging evidence has linked cell mechanics to functional behaviors [1]. The biophysical traits of a single cell are inextricably linked to the cytoskeleton. It has become increasingly evident that intrinsic and extrinsic mechanical properties, which… read more here.
Keywords: cell; ptpn21; mice; mll af9 ... See more keywords
Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1C
Sign Up to like & getrecommendations! Published in 2021 at "Oncogenesis"
DOI: 10.1038/s41389-021-00366-3
Abstract: Acute myeloid leukemia (AML) is a deadly cancer characterized by an expanded self-renewal capacity that is associated with the accumulation of immature myeloid cells. Emerging evidence shows that methyl-CpG-binding domain protein 2 (MBD2), a DNA… read more here.
Keywords: cell cycle; loss mbd2; mbd2; mll af9 ... See more keywords
High-fat diet intensifies MLL-AF9-induced acute myeloid leukemia through activation of the FLT3 signaling in mouse primitive hematopoietic cells
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73020-4
Abstract: Using a MLL-AF9 knock-in mouse model, we discovered that consumption of a high-fat diet (HFD) accelerates the risk of developing acute myeloid leukemia (AML). This regimen increases the clusterization of FLT3 within lipid rafts on… read more here.
Keywords: fat diet; primitive hematopoietic; high fat; mll af9 ... See more keywords
Abstract 6183: PARP inhibitors preferentially sensitize splicing factor mutant myeloid neoplasms
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6183
Abstract: Somatic heterozygous mutations in genes encoding for RNA splicing factors (SF) SRSF2, U2AF1, and SF3B1 are frequently mutated in patients with hematologic malignancies, representing a unique genetic vulnerability for targeted therapy. In the current study,… read more here.
Keywords: parp; srsf2p95h u2af1s34f; inhibitors preferentially; parp inhibitors ... See more keywords
miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-06-721027
Abstract: The hematopoietic stem cell-enriched miR-125 family microRNAs (miRNAs) are critical regulators of hematopoiesis. Overexpression of miR-125a or miR-125b is frequent in human acute myeloid leukemia (AML), and the overexpression of these miRNAs in mice leads… read more here.
Keywords: overexpression; mir 125b; non cell; mll af9 ... See more keywords
EVI1 in Acute Myeloid Leukemia Triggers Metabolic Reprograming Associated with Leukemogenesis and Increases Sensitivity to L-Aspalaginase
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DOI: 10.1182/blood-2018-99-111581
Abstract: Leukemia cells survive and proliferate under conditions of metabolic stress by acquiring mutations that increase energy metabolism. Here, we aimed to identify a specific metabolic inhibitor and examine transcription factor-enhanced changes in energy metabolism by… read more here.
Keywords: leukemia cells; energy; mll; mll af9 ... See more keywords
Myeloid Progenitors of Defined Features Provide Permissiveness to Leukemic Transformation
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DOI: 10.1182/blood.v130.suppl_1.1190.1190
Abstract: The conventional view of oncogenesis posits that driver mutations, when present in appropriate cell types, initiate malignant transformation. At the apex of the differentiation hierarchy, stem cells, such as hematopoietic stem cells, have been suggested… read more here.
Keywords: cell cycle; transformation; cell origin; mll af9 ... See more keywords
High Metabolic Dependence on Oxidative Phosphorylation Drives Sensitivity to Metformin Treatment in MLL/AF9 Acute Myeloid Leukemia
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DOI: 10.3390/cancers14030486
Abstract: Simple Summary Acute myeloid leukemia is a group of metabolic heterogeneous cancers, of which the long-term overall survival is still poor, especially in elderly patients. Targeting metabolic reprogramming in leukemic cells is becoming a promising… read more here.
Keywords: aml; acute myeloid; oxidative phosphorylation; myeloid leukemia ... See more keywords