MLL/WDR5 Complex Regulates Kif2A Localization to Ensure Chromosome Congression and Proper Spindle Assembly during Mitosis.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.05.023
Abstract: Mixed-lineage leukemia (MLL), along with multisubunit (WDR5, RbBP5, ASH2L, and DPY30) complex catalyzes the trimethylation of H3K4, leading to gene activation. Here, we characterize a chromatin-independent role for MLL during mitosis. MLL and WDR5 localize… read more here.
Keywords: mitosis; mll complex; mll; localization ... See more keywords
TRIB3 Modulates PPARĪ³-Mediated Growth Inhibition by Interfering with the MLL Complex in Breast Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810535
Abstract: Aberrant expression or activity of proteins are amongst the best understood mechanisms that can drive cancer initiation and progression, as well as therapy resistance. TRIB3, a member of the Tribbles family of pseudokinases, is often… read more here.
Keywords: cancer; mll complex; expression; breast cancer ... See more keywords