LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "mll enl" as a keyword



Photo from wikipedia

Tip60 activates Hoxa9 and Meis1 expression through acetylation of H2A.Z, promoting MLL-AF10 and MLL-ENL acute myeloid leukemia

Sign Up to like & get
recommendations! Published in 2021 at "Leukemia"

DOI: 10.1038/s41375-021-01244-y

Abstract: Chromosome translocations involving the MLL gene are common rearrangements in leukemia. Such translocations fuse the MLL 5’-region to partner genes in frame, producing MLL-fusions that cause MLL-related leukemia. MLL-fusions activate transcription of target genes such… read more here.

Keywords: mll enl; af10 mll; leukemia; mll ... See more keywords
Photo by thinkmagically from unsplash

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

Sign Up to like & get
recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-15220-0

Abstract: Leukaemogenic mutations commonly disrupt cellular differentiation and/or enhance proliferation, thus perturbing the regulatory programs that control self-renewal and differentiation of stem and progenitor cells. Translocations involving the Mll1 ( Kmt2a ) gene generate powerful oncogenic… read more here.

Keywords: model; mouse model; leukaemogenic transformation; mll enl ... See more keywords
Photo by nci from unsplash

Exploitable metabolic dependencies in MLL-ENL-induced leukemia.

Sign Up to like & get
recommendations! Published in 2020 at "Blood advances"

DOI: 10.1182/bloodadvances.2020001710

Abstract: Mixed-lineage leukemia (MLL) fusions are transcriptional activators that induce leukemia, with a dismal prognosis that mandates further elucidation of their transformation mechanism. In this study, knockdown of the direct MLL-ENL target gene polypyrimidine tract binding… read more here.

Keywords: mll enl; ser; ser gly; exploitable metabolic ... See more keywords
Photo from wikipedia

Myeloid transformation by MLL-ENL depends strictly on C/EBP

Sign Up to like & get
recommendations! Published in 2020 at "Life Science Alliance"

DOI: 10.26508/lsa.202000709

Abstract: This publication shows that C/EBP (CCAAT enhancer–binding protein) transcription factors are mandatory for maintaining the myeloid leukemic phenotype, suggesting a therapeutic option by interfering with the non-oncogenic C/EBP dependence. Chromosomal rearrangements of the mixed-lineage leukemia… read more here.

Keywords: transformation mll; mll; ebp; mll enl ... See more keywords