Restoration of microRNA function impairs MYC-dependent maintenance of MLL leukemia
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DOI: 10.1038/s41375-020-0768-2
Abstract: MicroRNAs (miRNAs) are a class of small noncoding RNAs that have critical functions in gene silencing by binding to complementary mRNAs to induce their degradation or translational repression [1]. Interestingly, only a small fraction of… read more here.
Keywords: leukemic cells; mll leukemic; function; mll ... See more keywords
PARPi potentiates with current conventional therapy in MLL leukemia
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DOI: 10.1080/15384101.2017.1288325
Abstract: ABSTRACT Acute myeloid leukemias driven by MLL fusion proteins are commonly associated with poor prognosis and refractory treatment. Here, we provide evidence that olaparib can potentiate sensitivity of MLL leukemia cells to conventional chemotherapy and… read more here.
Keywords: cell; mll; dnmt inhibitors; parpi potentiates ... See more keywords
Abstract 1175: Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia
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DOI: 10.1158/1538-7445.am2017-1175
Abstract: Novel targeted therapies are urgently needed for infant leukemia as this disease is highly aggressive and refractory to treatment resulting in poor survival rates. The NAD (Nicotinamide Adenine Dinucleotide) producing enzyme NAMPT (Nicotinamide Phosphoribosyltransferase) has… read more here.
Keywords: infant leukemia; therapeutic strategy; inhibition; leukemia ... See more keywords