Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation
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DOI: 10.1016/j.isci.2021.103679
Abstract: Summary Abnormal activation of SETBP1 due to overexpression or missense mutations occurs frequently in various myeloid neoplasms and associates with poor prognosis. Direct activation of Hoxa9/Hoxa10/Myb transcription by SETBP1 and its missense mutants is essential… read more here.
Keywords: setbp1; mll1 complex; activation; recruitment mll1 ... See more keywords
MLL1 is regulated by KSHV LANA and is important for virus latency
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1094
Abstract: Abstract Mixed lineage leukemia 1 (MLL1) is a histone methyltransferase. Kaposi's sarcoma-associated herpesvirus (KSHV) is a leading cause of malignancy in AIDS. KSHV latently infects tumor cells and its genome is decorated with epigenetic marks.… read more here.
Keywords: mll1 complex; mll1 regulated; lana; virus ... See more keywords