Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2021.103679
Abstract: Summary Abnormal activation of SETBP1 due to overexpression or missense mutations occurs frequently in various myeloid neoplasms and associates with poor prognosis. Direct activation of Hoxa9/Hoxa10/Myb transcription by SETBP1 and its missense mutants is essential… read more here.
Keywords: setbp1; mll1 complex; activation; recruitment mll1 ... See more keywords
MLL1 is regulated by KSHV LANA and is important for virus latency
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1094
Abstract: Abstract Mixed lineage leukemia 1 (MLL1) is a histone methyltransferase. Kaposi's sarcoma-associated herpesvirus (KSHV) is a leading cause of malignancy in AIDS. KSHV latently infects tumor cells and its genome is decorated with epigenetic marks.… read more here.
Keywords: mll1 complex; mll1 regulated; lana; virus ... See more keywords
MLL1 Complex Is a Critical Regulator of Fetal Hemoglobin Repression
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-199305
Abstract: Increasing fetal-type hemoglobin (HbF) expression in adult erythroid cells represents a promising strategy for treating β-globinopathies including sickle cell disease and β-thalassemia. However, the mechanisms responsible for the repression of HbF expression in adult erythroid… read more here.
Keywords: bcl11a; complex critical; mll1 complex; expression ... See more keywords