MLL4 keeps Foxp3 in the loop
Sign Up to like & getrecommendations! Published in 2017 at "Nature Immunology"
DOI: 10.1038/ni.3811
Abstract: The histone lysine methyltransferase MLL4 primes the locus encoding the transcription factor Foxp3 for transcriptional activation in thymus-derived and inducible regulatory T cells. read more here.
Keywords: keeps foxp3; mll4; foxp3 loop; mll4 keeps ... See more keywords
MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping
Sign Up to like & getrecommendations! Published in 2017 at "Nature immunology"
DOI: 10.1038/ni.3812
Abstract: MLL4 is an essential subunit of the histone H3 Lys4 (H3K4)-methylation complexes. We found that MLL4 deficiency compromised the development of regulatory T cells (Treg cells) and resulted in a substantial decrease in monomethylated H3K4… read more here.
Keywords: via chromatin; chromatin; chromatin looping; mll4 ... See more keywords
Interplay of BAF and MLL4 promotes cell type-specific enhancer activation
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DOI: 10.1038/s41467-021-21893-y
Abstract: Cell type-specific enhancers are activated by coordinated actions of lineage-determining transcription factors (LDTFs) and chromatin regulators. The SWI/SNF chromatin remodeling complex BAF and the histone H3K4 methyltransferase MLL4 (KMT2D) are both implicated in enhancer activation.… read more here.
Keywords: type specific; baf mll4; mll4; enhancer activation ... See more keywords