Rational design and synthesis of angiotensin-converting enzyme 2 inhibitors targeting severe acute respiratory syndrome coronavirus 2
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735074
Abstract: Objectives: The coronavirus disease 2019 (COVID-19) is still a global health concern caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The functional entry receptor utilized by SARS-CoV-2 is Angiotensin-Converting Enzyme 2 (ACE2). ACE2… read more here.
Keywords: inhibitors targeting; covid; physiology; mln 4760 ... See more keywords
MLN-4760 Induces Oxidative Stress without Blood Pressure and Behavioural Alterations in SHRs: Roles of Nfe2l2 Gene, Nitric Oxide and Hydrogen Sulfide
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DOI: 10.3390/antiox11122385
Abstract: Reduced angiotensin 1–7 bioavailability due to inhibition of angiotensin-converting enzyme 2 (ACE2) may contribute to increased mortality in hypertensive individuals during COVID-19. However, effects of ACE2 inhibitor MLN-4760 in brain functions remain unknown. We investigated… read more here.
Keywords: nitric oxide; expression; mln 4760; hydrogen sulfide ... See more keywords
Effects of Taxifolin in Spontaneously Hypertensive Rats with a Focus on Erythrocyte Quality
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DOI: 10.3390/life12122045
Abstract: Oxidative stress and multiple erythrocyte abnormalities have been observed in hypertension. We focused on the effects of angiotensin-converting enzyme 2 (ACE2) inhibition by MLN-4760 inhibitor on angiotensin peptides, oxidative stress parameters, and selected erythrocyte quality… read more here.
Keywords: taxifolin treatment; mln 4760; erythrocyte quality; taxifolin ... See more keywords