Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.102114
Abstract: Neddylation is essential for cardiomyocyte survival in the presence of oxidative stress, and it participates in autophagy regulation. However, whether MLN4924—an inhibitor of neddylation—exerts cardioprotective effects against myocardial ischemia/reperfusion (MI/R) remains unknown. In the present… read more here.
Keywords: sirt1; mln4924; myocardial ischemia; effect ... See more keywords
Nedd8-activating enzyme inhibitor MLN4924 (Pevonedistat), inhibits miR-1303 to suppress human breast cancer cell proliferation via targeting p27Kip1.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112038
Abstract: MLN4924/Pevonedistat, a Nedd8-activating enzyme (NAE, E1) inhibitor, has shown notable anti-cancer effect in pre-clinical trials, but it still faces tolerance resistance risk. Combination target therapy indicates a much better clinical effect than single target, and… read more here.
Keywords: cancer; mln4924; mir 1303; breast cancer ... See more keywords
MLN4924 suppresses tumor metabolism and growth of clear cell renal cell carcinoma by stabilizing nuclear FBP1
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02426-8
Abstract: Fructose-1, 6-bisphosphatase (FBP1) is a tumor suppressor and frequently deficient in various cancers, including clear cell renal cell carcinoma (ccRCC). VHL inactivation mutations are usually observed in ccRCC, which can lead to abnormal activation of… read more here.
Keywords: clear cell; fbp1; cell; growth ... See more keywords
MLN4924 (Pevonedistat), a protein neddylation inhibitor, suppresses proliferation and migration of human clear cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06098-y
Abstract: Neddylation is a post-translational protein modification associated with cancer development. MLN4924 is a neddylation inhibitor currently under investigation in multiple phase I studies on various malignancies, and its clincal name is Pevonedistat. It has been… read more here.
Keywords: mln4924; neddylation; migration; neddylation inhibitor ... See more keywords
Integrated transcriptome profiling and in vitro analysis reveals MLN4924's role in inducing ferroptosis in acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2025 at "Hematology"
DOI: 10.1080/16078454.2025.2497041
Abstract: ABSTRACT Objectives: While ferroptosis induction emerges as a therapeutic strategy for solid tumors, its role in acute myeloid leukemia (AML) remains unexplored. This study aimed to investigate the role of MLN4924 in modulating ferroptosis and… read more here.
Keywords: slc7a11 gpx4; role; acute myeloid; ferroptosis ... See more keywords
PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac067
Abstract: BACKGROUND Neddylation inhibition, affecting posttranslational protein function and turnover, is a promising therapeutic approach to cancer. We report vulnerability to MLN4924 or pevonedistat (a neddylation inhibitor) in a subset of glioblastoma (GBM) preclinical models and… read more here.
Keywords: neddylation inhibitor; neddylation; top2a inhibitors; mln4924 ... See more keywords
Celecoxib Synergistically Enhances MLN4924-Induced Cytotoxicity and EMT Inhibition Via AKT and ERK Pathways in Human Urothelial Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cell Transplantation"
DOI: 10.1177/09636897221077921
Abstract: MLN4924 is a specific small-molecule inhibitor of NEDD8-activating enzyme (NAE) that blocks the neddylation modification cascade. Several I/II/III clinical trials suggested that MLN4924 exerts an antitumor effect against various malignancies. However, recent studies have also… read more here.
Keywords: mln4924 induced; celecoxib; mln4924; erk ... See more keywords
MLN4924 inhibits macrophage foam cell formation by enhancing autophagy and regulating metabolic phenotype
Sign Up to like & getrecommendations! Published in 2025 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-025-02683-7
Abstract: MLN4924 is a novel small molecule inhibitor of neddylation. During clinical trials, it has demonstrated promising therapeutic efficacy in hematological malignancies, lung cancer, and colon cancer. MLN4924 possesses anti-inflammatory properties and promotes cardiomyocyte autophagy. Given… read more here.
Keywords: macrophage; foam; effects mln4924; formation ... See more keywords
Inhibiting Neddylation with MLN4924 Suppresses Growth and Delays Multicellular Development in Dictyostelium discoideum
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11030482
Abstract: Neddylation is a post-translational modification that is essential for a variety of cellular processes and is linked to many human diseases including cancer, neurodegeneration, and autoimmune disorders. Neddylation involves the conjugation of the ubiquitin-like modifier… read more here.
Keywords: multicellular development; mln4924; dictyostelium discoideum; neddylation ... See more keywords
MLN4924 Promotes Self-Renewal of Limbal Stem Cells and Ocular Surface Restoration
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm13030379
Abstract: Objective: To study the role of MLN4924 in corneal stem cell maintenance and corneal injury repair. Methods: In cell experiments, the Sprague–Dawley (SD) rat corneal epithelial cells were co-cultured with mitomycin C-inactivated mouse feeder cells… read more here.
Keywords: limbal stem; mln4924; corneal epithelial; mln4924 promotes ... See more keywords
MLN4924 promotes transcriptional activation of BTG2 via ROS/EGR1-mediated signaling axis to suppress acute myeloid leukemia progression
Sign Up to like & getrecommendations! Published in 2025 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2025194
Abstract: Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy characterized by a high relapse rate and a low survival rate. Although chemotherapy and allogeneic hematopoietic stem cell transplantation (allo-HSCT) have improved the prognosis for… read more here.
Keywords: ros; acute myeloid; aml; btg2 ... See more keywords