The absence of Rab27a accelerates the degradation of Melanophilin
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Dermatology"
DOI: 10.1111/exd.13840
Abstract: Melanophilin (Mlph) forms an interaction with Rab27a and the actinâbased motor protein MyosinVa (MyoVa) on mature melanosome membranes and the tripartite complex regulates melanosome transport in melanocytes. In this study, we found that Rab27a siRNA… read more here.
Keywords: degradation; melanophilin; rab27a; absence rab27a ... See more keywords
Identification of a Novel MLPH Missense Mutation in a Chinese Griscelli Syndrome 3 Patient
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.896943
Abstract: Melanophilin (MLPH) functions as a linker between RAB27A and myosin Va (MYO5A) in regulating skin pigmentation during the melanosome transport process. The MYO5A-MLPH-RAB27A ternary protein complex is required for anchoring mature melanosomes in the peripheral… read more here.
Keywords: missense mutation; patient; mlph; griscelli syndrome ... See more keywords