P11.02.A PRECLINICAL STUDY TO OVERCOME METHOTREXATE-RESISTANT MOUSE LEPTOMENINGEAL CARCINOMATOSIS: INTRATHECAL METHOTREXATE AND ORAL 6-THIOGUANINE
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DOI: 10.1093/neuonc/noaf193.341
Abstract: Leptomeningeal carcinomatosis (MC) is a severe complication of advanced cancer with limited therapeutic options. Methotrexate (MTX) is one of the most commonly used drugs for treating MC. However, MTX resistance is frequently observed before and… read more here.
Keywords: mtx; mtx mtx; mm46 cells; leptomeningeal carcinomatosis ... See more keywords