A Recognition Tag of Human Origin for Bioorthogonal Generation of Antibody‐Drug Conjugates using Microbial Biotin Ligase
Sign Up to like & getrecommendations! Published in 2025 at "Chembiochem"
DOI: 10.1002/cbic.202500261
Abstract: The use of enzymes, such as microbial transglutaminase, lipoate protein ligase A, or sortase A, for the generation of antibody‐drug conjugates has proven to be a powerful tool for the site‐specific payload conjugation to tumor‐specific… read more here.
Keywords: generation antibody; ligase; p67; mmae ... See more keywords
Monomethyl auristatin E-conjugated anti-EGFR antibody inhibits the growth of human EGFR-positive non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-019-03848-9
Abstract: PurposeEpidermal growth factor receptor (EGFR) is highly expressed on non-small cell lung cancers (NSCLC) and a valuable therapeutic target. This study aimed at producing and characterizing monomethyl auristatin E (MMAE)-conjugated anti-EGFR antibody as a novel… read more here.
Keywords: rc68 pab; mmae; egfr; pab mmae ... See more keywords
Chemotherapy-induced neuropathy in monomethyl Auristatin E treatment: prevention by lithium
Sign Up to like & getrecommendations! Published in 2025 at "British Journal of Cancer"
DOI: 10.1038/s41416-025-03020-6
Abstract: The increasing number of cancer survivors, thanks to improved cancer treatments, has escalated the prevalence of adverse effects, especially chemotherapy-induced peripheral neuropathy (CIPN) and chemotherapy-induced cognitive impairment (CICI). New drug classes, including antibody-drug conjugates (ADCs),… read more here.
Keywords: lithium; cancer; mmae; monomethyl auristatin ... See more keywords
Effectiveness of subdural evacuating port system (SEPS) and middle meningeal artery embolization (MMAE) for chronic subdural hematomas – a multicenter experience
Sign Up to like & getrecommendations! Published in 2025 at "Journal of NeuroInterventional Surgery"
DOI: 10.1136/jnis-2025-023489
Abstract: Background Craniotomy for subdural hematoma (SDH) in elderly patients with comorbidities can be challenging. The Subdural Evacuating Port System (SEPS; Medtronic, Minneapolis, MN) offers a less invasive alternative, while middle meningeal artery embolization (MMAE) has… read more here.
Keywords: seps mmae; mmae; subdural evacuating; port system ... See more keywords
Payload-binding Fab fragments increase the therapeutic index of MMAE antibody-drug conjugates.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-22-0440
Abstract: Monomethyl auristatin E (MMAE) is a potent tubulin inhibitor that is used as the payload for four FDA-approved antibody drug conjugates (ADCs). Deconjugated MMAE readily diffuses into untargeted cells resulting in off-target toxicity. Here we… read more here.
Keywords: cell; drug conjugates; mmae; administration abc3315 ... See more keywords
Broadening the Therapeutic Window of ADCs Using Site-Specific Bioconjugation Showcased by an MMAE-Containing Peptide Linker in a CD79b-Targeting ADC
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-24-0983
Abstract: Abstract The limitations of first-generation antibody–drug conjugate (ADC) technologies include suboptimal stability and efficacy, poor safety profiles, and challenging manufacturing processes. In this study, we describe an anti–CD79b-monomethyl auristatin E (MMAE) ADC generated using a… read more here.
Keywords: mmae; adc; anti cd79b; linker ... See more keywords
Abstract 3184: Development of an innovative bifunctional CPL976-MMAE conjugate based on a bispecific anti-PD-L1/ant-AXL antibody with a dual mechanism of action
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-3184
Abstract: Background: Tumor immunotherapy, especially the combination of PD-1/PD-L1 inhibitors and chemotherapy, has developed rapidly. However, the systemic side effects induced by chemotherapy remain a crucial problem that needs to be addressed. Antibody-drug conjugates (ADCs) are… read more here.
Keywords: cancer; mmae; cpl976 mmae; based bispecific ... See more keywords
Abstract LB004: Preclinical discovery and characterization of EO-1022, a site-specific glycan-conjugated anti-HER3 vc-MMAE ADC for treating solid tumors
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-lb004
Abstract: The overexpression of HER3 in solid tumors is associated with poor prognosis. Therapies developed to target HER3-mediated signaling are often associated with resistance over time, highlighting the need to develop differentiated therapeutic strategies. To address… read more here.
Keywords: cancer; mmae; solid tumors; patri dxd ... See more keywords
Abstract B40: Anti-EMP2 IgG Mono Methyl Auristatin E (MMAE) antibody-drug conjugate (ADC) as a potential cancer therapeutic
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.pmccavuln16-b40
Abstract: Despite significant advances in biology and medicine, the incidence and mortality due to cancer world-wide is still unacceptably high. With the goal of detection and eradication of disease, our overall strategy had been to identify… read more here.
Keywords: mmae; antibody; drug conjugate; anti emp2 ... See more keywords
Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy
Sign Up to like & getrecommendations! Published in 2019 at "Journal for Immunotherapy of Cancer"
DOI: 10.1186/s40425-019-0525-0
Abstract: BackgroundAberrant expression of the RON receptor tyrosine kinase is a pathogenic feature and a validated drug target in various types of cancers. Currently, therapeutic antibodies targeting RON for cancer therapy are under intensive evaluation. Here… read more here.
Keywords: mmae; pancreatic cancer; drug; cancer ... See more keywords
870 Middle Meningeal Artery Embolization Does Not Confer Protection Against Symptomatic Recurrence in Patients With Early Anticoagulation Following Surgery for Chronic Subdural Hematomas
Sign Up to like & getrecommendations! Published in 2024 at "Neurosurgery"
DOI: 10.1227/neu.0000000000002809_869
Abstract: INTRODUCTION: Chronic subdural hematoma (cSDH) is a prevalent condition that carries a significant burden. Middle meningeal artery embolization (MMAE) has emerged as a promising treatment both as an adjunct to surgery and as a primary… read more here.
Keywords: protection; surgery; mmae; middle meningeal ... See more keywords