Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP‐9 and MMP‐14
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13016
Abstract: MMP‐14 and MMP‐9 are two well‐established cancer targets for which no specific clinically relevant inhibitor is available. Using a powerful combination of computational design and yeast surface display technology, we engineered such an inhibitor starting… read more here.
Keywords: inhibitor; converting broad; mmp; timp2 ... See more keywords
MMP‐9‐dependent proteolysis of the histone H3 N‐terminal tail: a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13652
Abstract: Matrix metalloproteinase 9 (MMP‐9) is a member of the MMP family and has been recently identified as a nuclear protease capable of clipping histone H3 N‐terminal tails (H3NT). This MMP‐9‐dependent H3NT proteolysis is critical for… read more here.
Keywords: mmp; proteolysis; mmp dependent; colon ... See more keywords
Noninvasive Assessment of Protease Activity in Osteosarcoma via Click Chemistry‐Mediated Enrichment of Extracellular Vesicles
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202422469
Abstract: Osteosarcoma (OS), the most common bone cancer in children, is characterized by aggressive tumors and subclinical metastasis. Metastasis significantly impacts OS patient survival rate, highlighting the need for frequent assessment of disease progression and treatment… read more here.
Keywords: extracellular vesicles; mmp; chemistry; disease progression ... See more keywords
Active MMP-8 point-of-care (PoC)/chairside enzyme-test as an adjunctive tool for early and real-time diagnosis of peri-implantitis.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and experimental dental research"
DOI: 10.1002/cre2.537
Abstract: OBJECTIVE The aim of this study was to investigate the utility of the active matrix metalloproteinase (aMMP-8)-point-of-care (PoC) test as a quantitative real-time chair-side diagnostic tool for peri-implant diagnosis, as well as assess the potentially… read more here.
Keywords: peri; real time; ammp poc; test ... See more keywords
Relation between post‐myocardial infarct remodelling and gelatinase activity in patients enrolled in the TIPTOP trial
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1361
Abstract: In pre-clinical studies, matrix metalloproteinase (MMP) inhibition, particularly gelatinases (MMP-2 and -9), attenuated post-myocardial infarct (MI) remodelling.1 However, synthetic inhibitors of MMPs in the clinical setting have yielded disappointing results.2 For the first time, the… read more here.
Keywords: trial; mmp; post myocardial; post ... See more keywords
MicroRNA‐193b‐3p regulates matrix metalloproteinase 19 expression in interleukin‐1β‐induced human chondrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26669
Abstract: Micro(mi)RNAs are small, non‐coding RNA molecules known to play a significant role in osteoarthritis (OA) initiation and development, and similar to matrix metalloproteinases (MMPs), they participate in cartilage degeneration and cleave multiple extracellular matrices. The… read more here.
Keywords: induced human; interleukin induced; human chondrocytes; mmp ... See more keywords
Matrix metalloproteinase‐13 is a target gene of high‐mobility group box‐containing protein 1 in modulating oral cancer cell invasion
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27223
Abstract: Transcription factor high‐mobility group box‐containing protein 1 (HBP1) may function as a tumor suppressor in various types of cancer. In a previous study, we demonstrated that HBP1 suppressed cell invasion in oral cancer. To further… read more here.
Keywords: invasion; oral cancer; mmp; hbp1 ... See more keywords
Identification of binding partners that facilitate membrane‐type 5 matrix metalloproteinase (MT5‐MMP) processing of amyloid precursor protein
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31218
Abstract: One of the pathological hallmarks of Alzheimer's disease (AD) is the presence of extracellular deposits of amyloid beta (Aβ) peptide. In addition to Aβ as the core component of the amyloid plaque, the amyloid precursor… read more here.
Keywords: mmp; mt5 mmp; amyloid; protein ... See more keywords
TIMP‐2 as a Potential Indicator of Persistent Arthralgia in Chikungunya: Evidence From a Brazilian Cohort Study
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70635
Abstract: Chikungunya virus (CHIKV) infection can trigger a sustained inflammatory response, often leading to chronic musculoskeletal pain. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) may contribute to the persistence of arthralgia through their involvement in… read more here.
Keywords: mmp; chikungunya; mmp mmp; persistent arthralgia ... See more keywords
Smoking confounds the periodontal diagnostics using saliva biomarkers.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontology"
DOI: 10.1002/jper.18-0545
Abstract: BACKGROUND Smoking is a risk factor for periodontal disease because of its complex impact on the inflammatory response in the periodontium. We investigated the effect of smoking on salivary periodontal biomarkers, matrix metalloproteinase (MMP)-8, MMP-9,… read more here.
Keywords: mmp; smoking confounds; since cessation; saliva biomarkers ... See more keywords
Gingival crevicular fluid semaphorin 4D and peptidylarginine deiminase two levels in periodontal health and disease.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontology"
DOI: 10.1002/jper.18-0608
Abstract: BACKGROUND The aim of this study was to compare the levels of semaphorin 4D (SEMA4D), peptidylarginine deiminase 2 (PAD2) and matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid (GCF) in patients with periodontal disease and patients… read more here.
Keywords: mmp; total amounts; peptidylarginine deiminase; sema4d pad2 ... See more keywords