Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP‐9 and MMP‐14
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13016
Abstract: MMP‐14 and MMP‐9 are two well‐established cancer targets for which no specific clinically relevant inhibitor is available. Using a powerful combination of computational design and yeast surface display technology, we engineered such an inhibitor starting… read more here.
Keywords: inhibitor; converting broad; mmp; timp2 ... See more keywords
Active MMP-8 point-of-care (PoC)/chairside enzyme-test as an adjunctive tool for early and real-time diagnosis of peri-implantitis.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and experimental dental research"
DOI: 10.1002/cre2.537
Abstract: OBJECTIVE The aim of this study was to investigate the utility of the active matrix metalloproteinase (aMMP-8)-point-of-care (PoC) test as a quantitative real-time chair-side diagnostic tool for peri-implant diagnosis, as well as assess the potentially… read more here.
Keywords: peri; real time; ammp poc; test ... See more keywords
Relation between post‐myocardial infarct remodelling and gelatinase activity in patients enrolled in the TIPTOP trial
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1361
Abstract: In pre-clinical studies, matrix metalloproteinase (MMP) inhibition, particularly gelatinases (MMP-2 and -9), attenuated post-myocardial infarct (MI) remodelling.1 However, synthetic inhibitors of MMPs in the clinical setting have yielded disappointing results.2 For the first time, the… read more here.
Keywords: trial; mmp; post myocardial; post ... See more keywords
MicroRNA‐193b‐3p regulates matrix metalloproteinase 19 expression in interleukin‐1β‐induced human chondrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26669
Abstract: Micro(mi)RNAs are small, non‐coding RNA molecules known to play a significant role in osteoarthritis (OA) initiation and development, and similar to matrix metalloproteinases (MMPs), they participate in cartilage degeneration and cleave multiple extracellular matrices. The… read more here.
Keywords: induced human; interleukin induced; human chondrocytes; mmp ... See more keywords
Matrix metalloproteinase‐13 is a target gene of high‐mobility group box‐containing protein 1 in modulating oral cancer cell invasion
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27223
Abstract: Transcription factor high‐mobility group box‐containing protein 1 (HBP1) may function as a tumor suppressor in various types of cancer. In a previous study, we demonstrated that HBP1 suppressed cell invasion in oral cancer. To further… read more here.
Keywords: invasion; oral cancer; mmp; hbp1 ... See more keywords
Smoking confounds the periodontal diagnostics using saliva biomarkers.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontology"
DOI: 10.1002/jper.18-0545
Abstract: BACKGROUND Smoking is a risk factor for periodontal disease because of its complex impact on the inflammatory response in the periodontium. We investigated the effect of smoking on salivary periodontal biomarkers, matrix metalloproteinase (MMP)-8, MMP-9,… read more here.
Keywords: mmp; smoking confounds; since cessation; saliva biomarkers ... See more keywords
Gingival crevicular fluid semaphorin 4D and peptidylarginine deiminase two levels in periodontal health and disease.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontology"
DOI: 10.1002/jper.18-0608
Abstract: BACKGROUND The aim of this study was to compare the levels of semaphorin 4D (SEMA4D), peptidylarginine deiminase 2 (PAD2) and matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid (GCF) in patients with periodontal disease and patients… read more here.
Keywords: mmp; total amounts; peptidylarginine deiminase; sema4d pad2 ... See more keywords
Periodontal inflammation and distinct inflammatory profiles in saliva and GCF compared with serum and joints in rheumatoid arthritis patients.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of periodontology"
DOI: 10.1002/jper.20-0051
Abstract: BACKGROUND The association of periodontitis and Porphyromonas gingivalis (Pg) with rheumatoid arthritis (RA) is incompletely understood. To gain further insights, we evaluated periodontal status, oral, serum and joint inflammatory profiles, and Pg biomarkers in RA… read more here.
Keywords: mmp; mmp mmp; periodontitis; rheumatoid arthritis ... See more keywords
Clinical, histological, immunohistochemical and biomolecular analysis of hyaluronic acid in early wound healing of human gingival tissues: A randomized, split-mouth trial.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of periodontology"
DOI: 10.1002/jper.22-0338
Abstract: BACKGROUND Hyaluronic acid (HA) exerts a fundamental role in tissue repair. In vitro and animal studies demonstrated its ability to enhance wound healing. Nevertheless, in vivo human studies evaluating mechanisms involved in oral soft tissue… read more here.
Keywords: gingival tissues; early wound; wound healing; hyaluronic acid ... See more keywords
Effects of lipopolysaccharide, multiwalled carbon nantoubes, and the combination on lung alveolar epithelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Toxicology"
DOI: 10.1002/tox.22248
Abstract: Multiwalled carbon nanotubes (MWCNT) have been shown to induce lung fibrosis in animal models, however the underlying molecular factors/mechanisms are still unclear. In this study, we investigated the effects of lipopolysaccharide (LPS), MWCNT, and the… read more here.
Keywords: combination; epithelial cells; lps mwcnt; mmp ... See more keywords
Increased substance P-like immunoreactivities in parabrachial and amygdaloid nuclei in a rat model with masticatory myofascial pain.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental brain research"
DOI: 10.1007/s00221-020-05942-4
Abstract: This study explores the involvement of substance P (SP) in the parabrachial nucleus (PBN) and central amygdaloid nucleus (CeA) in the nociception-emotion link and of rats with masticatory myofascial pain (MMP) induced by chronic tetanic… read more here.
Keywords: substance; muscle; mmp; masticatory myofascial ... See more keywords