Stenosis Hemodynamics Disrupt the Endothelial Cell Glycocalyx by MMP Activity Creating a Proinflammatory Environment
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-017-1846-0
Abstract: Hemodynamic forces are known to be able to induce an inflammatory phenotype in endothelial cells (ECs). The EC glycocalyx (GCX) is a dynamic structure which is regulated in response to different stimuli and hypothesized as… read more here.
Keywords: proinflammatory environment; stenosis; hemodynamics; mmp activity ... See more keywords
Sialic acid removal by trans-sialidase modulates MMP-2 activity during Trypanosoma cruzi infection
Sign Up to like & getrecommendations! Published in 2021 at "Biochimie"
DOI: 10.1016/j.biochi.2021.04.005
Abstract: Matrix metalloproteinases (MMPs) not only play a relevant role in homeostatic processes but are also involved in several pathological mechanisms associated with infectious diseases. As their clinical relevance in Chagas disease has recently been highlighted,… read more here.
Keywords: trans sialidase; activity; cruzi infection; mmp activity ... See more keywords
Epithelial-mesenchymal crosstalk influences cellular behavior in a 3D alveolus-fibroblast model system.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.11.008
Abstract: Interactions between lung epithelium and interstitial fibroblasts are increasingly recognized as playing a major role in the progression of several lung pathologies, including cancer. Three-dimensional in vitro co-culture systems offer tissue-relevant platforms to study the signaling… read more here.
Keywords: mesenchymal crosstalk; epithelial mesenchymal; cancer; mmp activity ... See more keywords
A polysaccharide from Sargassum thunbergii inhibits angiogenesis via downregulating MMP-2 activity and VEGF/HIF-1α signaling.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2016.10.046
Abstract: A water-soluble polysaccharide (STPC2) was isolated from the boiling-water extract of Sargassum thunbergii, purified by CaCl2 precipitation and chromatography on DEAE-cellulose and Sephacryl S-300 column. It was found that STPC2, with a molecular weight of… read more here.
Keywords: hif; vegf hif; activity vegf; sargassum thunbergii ... See more keywords
Tissue Inhibitor of Metalloproteinase (TIMP) Peptidomimetic as an Adjunctive Therapy for Infectious Keratitis.
Sign Up to like & getrecommendations! Published in 2020 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.0c01473
Abstract: Matrix metalloproteinase 9 (MMP-9) has a key role in many biological processes, and while it is crucial for a normal immune response, excessive release of this enzyme can lead to severe tissue damage, as evidenced… read more here.
Keywords: infectious keratitis; metalloproteinase; timp peptidomimetic; tissue ... See more keywords
Gold Nanorods Inhibit Tumor Metastasis by Regulating MMP-9 Activity: Implications for Radiotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c20944
Abstract: Dysregulation of matrix metalloproteinase (MMP) is strongly implicated in tumor invasion and metastasis. Nanomaterials can interact with proteins and have impacts on protein activity, which provides a potential strategy for inhibiting tumor invasion and metastasis.… read more here.
Keywords: metastasis; gold nanorods; mmp activity; activity ... See more keywords
Serpine1 Knockdown Enhances MMP Activity after Flexor Tendon Injury in Mice: Implications for Adhesions Therapy
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-24144-1
Abstract: Injuries to flexor tendons can be complicated by fibrotic adhesions, which severely impair the function of the hand. Adhesions have been associated with TGF-β1, which causes upregulation of PAI-1, a master suppressor of protease activity,… read more here.
Keywords: mmp activity; flexor tendon; activity; tendon injury ... See more keywords
The invasiveness of human cervical cancer associated to the function of NaV1.6 channels is mediated by MMP-2 activity
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31364-y
Abstract: Voltage-gated sodium (NaV) channels have been related with cell migration and invasiveness in human cancers. We previously reported the contribution of NaV1.6 channels activity with the invasion capacity of cervical cancer (CeCa) positive to Human… read more here.
Keywords: invasiveness human; nav1 channels; ceca; cancer ... See more keywords
Assessment of solid microneedle rollers to enhance transmembrane delivery of doxycycline and inhibition of MMP activity
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery"
DOI: 10.1080/10717544.2017.1337826
Abstract: Abstract Many chronic wounds exhibit high matrix metalloproteinase (MMP) activity that impedes the normal wound healing process. Intradermal delivery (IDD) of sub-antimicrobial concentrations of doxycycline, as an MMP inhibitor, could target early stages of chronic… read more here.
Keywords: mmp activity; delivery; microneedle rollers; doxycycline ... See more keywords
A11010 Changes of extracellular matrix metalloproteinase-2 of isoproterenol injured normotensive and hypertensive rats are hampered by treatment with omega-3 fatty acids and melatonin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548231.96451.03
Abstract: Objectives: Experimental and clinical studies suggest that melatonin and omega-3 fatty acids (PUFA) are cardioprotective, but underlying molecular mechanisms are still not fully explored. We hypothesize that both compounds may affect extracellular matrix remodeling by… read more here.
Keywords: iso; hypertensive rats; extracellular matrix; mmp activity ... See more keywords
Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01412-16
Abstract: ABSTRACT Mouse adenovirus type 1 (MAV-1) infection causes encephalitis in susceptible strains of mice and alters the permeability of infected brains to small molecules, which indicates disruption of the blood-brain barrier (BBB). Under pathological conditions,… read more here.
Keywords: mmp activity; activity; mouse; mav infection ... See more keywords