Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111563
Abstract: Matrix metalloproteinases (MMPs) play important roles in many diseases including cancer. With moderate metal-binding affinity, 8-hydroxyquinoline has gained much interest in current drug design and development. Specially, it has been reported that 8-hydroxyquinoline derivatives serve… read more here.
Keywords: mmp; mmp mmp; design synthesis; synthesis preliminary ... See more keywords
Design, (Radio)Synthesis, and in Vitro and in Vivo Evaluation of Highly Selective and Potent Matrix Metalloproteinase 12 (MMP-12) Inhibitors as Radiotracers for Positron Emission Tomography.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00200
Abstract: Dysregulated levels of activated matrix metalloproteinases (MMPs) are linked to different pathologies, such as cancer, atherosclerosis, neuroinflammation, and arthritis. Therefore, imaging of MMPs with positron-emission tomography (PET) represents a powerful tool for the diagnosis of… read more here.
Keywords: matrix; mmp; positron emission; vitro ... See more keywords
MMP Inhibitors and Dentin Bonding: Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Dentistry"
DOI: 10.1155/2021/9949699
Abstract: Objectives Resin-dentin bond strength decreases over time. This reduction is related to the loss of hybrid layer integrity. Collagenolytic enzymes, especially matrix metalloproteinases (MMPs), are responsible for the degradation of the collagen matrix of the… read more here.
Keywords: analysis; dentin bond; mmp inhibitors; meta analysis ... See more keywords
Matrixmetalloproteinase Inhibitors: Promising Therapeutic Targets Against Cancer.
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DOI: 10.2174/1381612827666210830103059
Abstract: BACKGROUND Cancer is a wide range cellular level disease that occurs when cells go through uncontrolled division and growth. The mechanisms by which the cells undergo metastasis are complex and involve many interactions between the… read more here.
Keywords: promising therapeutic; inhibitors promising; matrixmetalloproteinase inhibitors; clinical trials ... See more keywords
Synthesis and Evaluation of A New Series of Thiazole Derivatives as Potential Antitumor Agents and MMP Inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520616666160802113620
Abstract: BACKGROUND In recent years, the relationship between overexpression of matrix metalloproteinases (MMPs) and tumor invasion/metastasis has prompted researchers to develop MMP inhibitors as anticancer drugs. OBJECTIVE The aim of this study was to design and… read more here.
Keywords: mcf; mmp inhibitors; mmp; thiazole derivatives ... See more keywords
Identification of Zinc-Binding Inhibitors of Matrix Metalloproteinase-9 to Prevent Cancer Through Deep Learning and Molecular Dynamics Simulation Approach
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.857430
Abstract: The overexpression of matrix metalloproteinase-9 (MMP-9) is associated with tumor development and angiogenesis, and hence, it has been considered an attractive drug target for anticancer therapy. To assist in drug design endeavors for MMP-9 targets,… read more here.
Keywords: mmp inhibitors; zinc; molecular dynamics; deep learning ... See more keywords
Matrix metalloproteinases as therapeutic targets in breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1108695
Abstract: Matrix metalloproteinases (MMPs) are the most prominent proteinases involved in tumorigenesis. They were initially recognized to promote tumor progression by remodeling the extracellular matrix through their proteolytic activity. However, accumulating evidence has revealed that some… read more here.
Keywords: mmp inhibitors; breast cancer; matrix metalloproteinases; tumor ... See more keywords