Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP‐9 and MMP‐14
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13016
Abstract: MMP‐14 and MMP‐9 are two well‐established cancer targets for which no specific clinically relevant inhibitor is available. Using a powerful combination of computational design and yeast surface display technology, we engineered such an inhibitor starting… read more here.
Keywords: inhibitor; converting broad; mmp; timp2 ... See more keywords
Periodontal inflammation and distinct inflammatory profiles in saliva and GCF compared with serum and joints in rheumatoid arthritis patients.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of periodontology"
DOI: 10.1002/jper.20-0051
Abstract: BACKGROUND The association of periodontitis and Porphyromonas gingivalis (Pg) with rheumatoid arthritis (RA) is incompletely understood. To gain further insights, we evaluated periodontal status, oral, serum and joint inflammatory profiles, and Pg biomarkers in RA… read more here.
Keywords: mmp; mmp mmp; periodontitis; rheumatoid arthritis ... See more keywords
Effect of a structured plaque control on MMP-1 and MMP-9 crevicular levels in patients with desquamative gingivitis associated with oral lichen planus
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-018-2704-7
Abstract: ObjectivesNo data are available in the literature on the extent to which the immune host-response and bacterial-elicited inflammation separately contributes to the increase in gingival crevicular fluid (GCF) levels of inflammatory biomarkers in patients affected… read more here.
Keywords: control; structured plaque; mmp mmp; plaque control ... See more keywords
Comparative Analysis of MMP-8 and MMP-9 Concentrations in Crevicular and Peri-Implants Sulcular Fluids.
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of experimental biology and medicine"
DOI: 10.1007/s10517-020-04996-2
Abstract: The concentrations of MMP-8 and MMP-9 were measured in the crevicular and the peri-implant sulcular fluids at the different stages of the prosthetic treatment. The concentration MMP-8 and MMP-9 in the peri-implant sulcular fluids were… read more here.
Keywords: crevicular peri; sulcular fluids; analysis; peri implant ... See more keywords
Paeonol Inhibits IL-1β-Induced Inflammation via PI3K/Akt/NF-κB Pathways: In Vivo and Vitro Studies
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation"
DOI: 10.1007/s10753-017-0611-8
Abstract: Paeonol, the main active component isolated from the root of Paeonia suffruticosa, has been reported to have anti-inflammatory properties. However, the effects of paeonol on osteoarthritis (OA) remain unclear. The aim of this study was… read more here.
Keywords: paeonol; mmp mmp; inflammation; pi3k akt ... See more keywords
Zinc Deficiency Aggravation of ROS and Inflammatory Injury Leading to Renal Fibrosis in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Biological Trace Element Research"
DOI: 10.1007/s12011-020-02184-x
Abstract: Zinc (Zn) is a trace element with a variety of anti-inflammatory and antioxidant effects. Zn deficiency is related to tissue fibrosis. The present study was designed to investigate the effect of Zn on renal fibrosis.… read more here.
Keywords: fibrosis; renal fibrosis; expression; mmp mmp ... See more keywords
The Effect of BSA-Based Curcumin Nanoparticles on Memory and Hippocampal MMP-2, MMP-9, and MAPKs in Adult Mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1104-4
Abstract: Although high rate of curcumin consumption has been suggested to decrease the prevalence of Alzheimer’s disease (AD), its administration has no effect on the progression of AD in humans and this has been attributed to… read more here.
Keywords: mmp; effect; mmp mapks; mmp mmp ... See more keywords
RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biosciences"
DOI: 10.1007/s12038-020-00056-z
Abstract: Up-regulation of MMP-2 and MMP-9 plays a significant role in promoting cancer progression by degrading the components of the extracellular matrix, thereby enhancing the migration of tumor cells. Although the anti-proliferative and apoptotic effect of… read more here.
Keywords: mmp; muricata; mmp mmp; inhibition mmp ... See more keywords
Expression of matrix metalloproteinases-2, -9 and reversion-inducing cysteine-rich protein with Kazal motifs in gingiva in periodontal health and disease.
Sign Up to like & getrecommendations! Published in 2017 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2016.12.009
Abstract: BACKGROUND AND OBJECTIVE Periodontitis is characterized by pathological destruction of extracellular matrix (ECM) of periodontal tissues. Matrix metalloproteinases (MMPs) promote the occurrence and development of periodontitis by degrading almost all proteins of ECM. RECK (reversion-inducing-cysteine-rich… read more here.
Keywords: protein; expression; reck; mmp mmp ... See more keywords
Biphenyl substituted lysine derivatives as recognition elements for the matrix metalloproteinases MMP-2 and MMP-9.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105155
Abstract: Matrix metalloproteinases (MMPs) are an important factor in cancer progression and metastasis, especially gelatinases MMP-2 and MMP-9. A simple methodology for their detection and monitoring is highly desirable. Molecular probes have been very widely and… read more here.
Keywords: substituted lysine; mmp; lysine derivatives; biphenyl substituted ... See more keywords
Promotion of Wilms' tumor cells migration and invasion by mono-2-ethyhexyl phthalate (MEHP) via activation of NF-κB signals.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.04.004
Abstract: Wilms tumor is a pediatric kidney cancer associated with inactivation of the WT1 tumor-suppressor gene in 5-10% of cases. There is an urgent need to illustrate risk factors which can trigger the motility of Wilms… read more here.
Keywords: mmp mmp; mmp; mehp; wilms tumor ... See more keywords