A comparison of human mesenchymal stem cell osteogenesis in poly(ethylene glycol) hydrogels as a function of MMP‐sensitive crosslinker and crosslink density in chemically defined medium
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26957
Abstract: This study investigated osteogenesis of human mesenchymal stem cells encapsulated in matrix‐metalloproteinase (MMP)‐sensitive poly(ethylene glycol) (PEG) hydrogels in chemically defined medium (10 ng/ml bone morphogenic factor‐2). Thiol‐norbornene photoclick hydrogels were formed with CRGDS and crosslinkers of… read more here.
Keywords: defined medium; mmp sensitive; osteogenesis; cell ... See more keywords
An MMP-2 sensitive and reduction-responsive prodrug amphiphile for actively targeted therapy of cancer by hierarchical cleavage.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc05586d
Abstract: A hierarchically cleaved amphiphile, mPEG-pep-etcSS-CPT, was synthesized to pursue actively targeted cancer therapy through self-assembly. This micelle can respond to MMP-2 achieving dePEGylation and releasing RGD peptides to be internalized into targetable tumor cells. Inside… read more here.
Keywords: mmp sensitive; actively targeted; cancer; sensitive reduction ... See more keywords
Dual Functionalized Liposomes for Selective Delivery of Poorly Soluble Drugs to Inflamed Brain Regions
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DOI: 10.3390/pharmaceutics14112402
Abstract: Dual functionalized liposomes were developed to cross the blood–brain barrier (BBB) and to release their cargo in a pathological matrix metalloproteinase (MMP)-rich microenvironment. Liposomes were surface-functionalized with a modified peptide deriving from the receptor-binding domain… read more here.
Keywords: mmp sensitive; brain; functionalized liposomes; dual functionalized ... See more keywords