CXCL17-mediated downregulation of type I collagen via MMP1 and miR-29 in skin fibroblasts possibly contributes to the fibrosis in systemic sclerosis.
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DOI: 10.1016/j.jdermsci.2020.09.010
Abstract: BACKGROUND Systemic sclerosis (SSc) is characterized by excessive deposition of collagen in the skin and internal organs. Recent studies have shown that chemokine (C-X-C motif) ligands (CXCLs) are involved in the pathogenesis of SSc. OBJECTIVE… read more here.
Keywords: collagen; mmp1 mir; skin; cxcl17 ... See more keywords